مورد إلكتروني
Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century.
العنوان: | Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century. |
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المصدر: | Cerebellum, 8 (3 |
بيانات النشر: | 2009-09 |
تفاصيل مُضافة: | Manto, Mario Marmolino, Daniele |
نوع الوثيقة: | Electronic Resource |
مستخلص: | Cerebellar ataxias represent a group of disabling neurological disorders. Our understanding of the pathogenesis of cerebellar ataxias is continuously expanding. A considerable number of laboratory animals with neurological mutations have been reported and numerous relevant animal models mimicking the phenotype of cerebellar ataxias are becoming available. These models greatly help dissecting the numerous mechanisms of cerebellar dysfunction, a major step for the assessment of therapeutics targeting a given deleterious pathway and for the screening of old or newly synthesized chemical compounds. Nevertheless, differences between animal models and human disorders should not be overlooked and difficulties in terms of characterization should not be occulted. The identification of the mutations of many hereditary ataxias, the development of valuable animal models, and the recent identifications of the molecular mechanisms underlying cerebellar disorders represent a combination of key factors for the development of anti-ataxic innovative therapies. It is anticipated that the twenty-first century will be the century of effective therapies in the field of cerebellar ataxias. The animal models are a cornerstone to reach this goal. Journal Article Research Support, Non-U.S. Gov't SCOPUS: re.j info:eu-repo/semantics/published |
مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Cerebellar Ataxia -- therapy, Disease Models, Animal, Humans, Animal models, Ataxias, Cerebellum, Pathogenesis, Therapies, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
URL: | |
الإتاحة: | Open access content. Open access content 1 full-text file(s): info:eu-repo/semantics/restrictedAccess |
ملاحظة: | 1 full-text file(s): application/pdf English |
أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/55048 uri/info:doi/10.1007/s12311-009-0127-3 uri/info:pmid/19669387 uri/info:scp/69549116455 764589514 |
المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
رقم الأكسشن: | edsoai.ocn764589514 |
قاعدة البيانات: | OAIster |
الوصف غير متاح. |