مورد إلكتروني
Effect of the antibiotic azithromycin on thermotropic behavior of DOPC or DPPC bilayers.
| العنوان: | Effect of the antibiotic azithromycin on thermotropic behavior of DOPC or DPPC bilayers. |
|---|---|
| المصدر: | Chemistry and physics of lipids, 144 (1 |
| بيانات النشر: | 2006-10 |
| تفاصيل مُضافة: | Fa, Nathalie Ronkart, S Schanck, André Deleu, Magali Gaigneaux, Anthoula Goormaghtigh, Erik Mingeot-Leclercq, Marie-Paule |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Azithromycin is a macrolide antibiotic known to bind to lipids and to affect endocytosis probably by interacting with lipid membranes [Tyteca, D. Schanck, A. Dufrene, Y.F. Deleu, M. Courtoy, P.J. Tulkens, P.M. Mingeot-Leclercq, M.P. 2003. The macrolide antibiotic azithromycin interacts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages. J. Membr. Biol. 192, 203-215]. In this work, we investigate the effect of azithromycin on lipid model membranes made of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Thermal transitions of both lipids in contact with azithromycin are studied by (31)P NMR and DSC on multilamellar vesicles. Concerning the DPPC, azithromycin induces a suppression of the pretransition whereas a phase separation between the DOPC and the antibiotic is observed. For both lipids, the enthalpy associated with the phase transition is strongly decreased with azithromycin. Such effects may be due to an increase of the available space between hydrophobic chains after insertion of azithromycin in lipids. The findings provide a molecular insight of the phase merging of DPPC gel in DOPC fluid matrix induced by azithromycin [Berquand, A. Mingeot-Leclercq, M.P. Dufrene, Y.F. 2004. Real-time imaging of drug-membrane interactions by atomic force microscopy. Biochim. Biophys. Acta 1664, 198-205] and could help to a better understanding of azithromycin-cell interaction. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Chimie, Anti-Bacterial Agents -- chemistry, Azithromycin -- chemistry, Calorimetry, Differential Scanning, Lipid Bilayers -- chemistry, Magnetic Resonance Spectroscopy, Phase Transition, Phosphatidylcholines -- chemistry, Phosphorus Radioisotopes -- chemistry, Phosphorylcholine -- analogs & derivatives, Phosphorylcholine -- chemistry, Spectrophotometry, Infrared, Temperature, Azithromycin: DOPC, DPPC, DSC, FT-IR, NMR, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content 2 full-text file(s): info:eu-repo/semantics/restrictedAccess | info:eu-repo/semantics/closedAccess |
| ملاحظة: | 2 full-text file(s): application/pdf | application/pdf English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/74213 uri/info:doi/10.1016/j.chemphyslip.2006.08.002 uri/info:pii/S0009-3084(06)00143-5 uri/info:pmid/17007828 uri/info:scp/33749577859 764621227 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn764621227 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |