مورد إلكتروني
Koncentracije malondialdehida i antioksidativnih vitamina iz krvi majke i pupkovine kod majki oboljelih od preeklampsije i zdravih majki
| العنوان: | Koncentracije malondialdehida i antioksidativnih vitamina iz krvi majke i pupkovine kod majki oboljelih od preeklampsije i zdravih majki |
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| عناروين إضافية: | Maternal and cord blood malondialdehyde and antioxidant vitamin levels in normal and preeclamptic women |
| المصدر: | Biochemia Medica; ISSN 1330-0962 (Print); ISSN 1846-7482 (Online); Volume 19; Issue 2 |
| بيانات النشر: | Medicinska naklada 2009 |
| تفاصيل مُضافة: | Mohd Suhail Mohd Faizul-Suhail |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Uvod: Cilj nam je bio odrediti odnos između peroksidacije lipoproteina i an-tioksidacijskog kapaciteta krvi majke i krvi iz pupkovine te ispitati razlikuju li se koncentracije malondialdehida i vitamina E, A i C u plazmi majke i pupkovine između trudnica oboljelih od preeklampsije i zdravih trudnica. Metode: Usporedili smo oksidacijski i antioksidacijski sustav u krvi majke i krvi iz pupkovine kod dviju skupina majki i njihove novorođenčadi. Njihove su koncentracije malondialdehida (engl. malondialdehyde, MDA) i antioksidacijskih vitamina E, A i C u krvi određene i uspoređene, kako bi se procijenilo razlikuje li se prooksidacijski status majke s preeklampsijom od statusa u krvi iz pupkovine kod odgovarajućeg novorođenčeta. Rezultati: Koncentracija MDA u plazmi majki s preeklampsijom bila je značajno viša (P < 0,001) nego kod kontrolne skupine, no njegova je koncentracija bila značajno niža u krvi iz pupkovine kod majki s preeklampsijom. Koncentracije MDA bile su značajno niže (P < 0,001) u plazmi iz pupkovine u usporedbi s koncentracijom u plazmi majke. Koncentracija vitamina E bila je niža u plazmi majki s težim oblikom preeklampsije (P = 0,048). Koncentracija vitamina A bila je statistički značajno niža (P = 0,009) u plazmi majki s preeklampsijom u usporedbi s kontrolnom skupinom. Zanimljivo je da nije bilo statistički značajne razlike u koncentracijama u krvi majke i krvi iz pupkovine kod bolesnica s težim oblikom preeklampsije. Međutim, u plazmi iz pupkovine, izmjerena je znatno niža koncentracija vitamina A nego u plazmi majke. Za razliku od vitamina E i A, koncentracija vitamina C u plazmi krvi iz pupkovine bila je znatno viša kod obiju skupina. Zaključak: Pretpostavljamo da je antioksidacijski kapacitet krvi iz pupkovine dovoljan te da je placentalna barijera odgovarajuća za zaštitu fetusa od oksidacijskog oštećenja izazvanog oksidacijskim stresom kod majki s preeklampsijom. Stoga zaključujemo da je status oksidacijskog stresa u krvi novorođenčeta nizak u usp Introduction: We aimed to assess the relationship between lipoperoxidation and maternal/cord blood antioxidant capacity and to examine whether the maternal and cord plasma concentrations of malondialdehyde and of vitamins E, A, and C were different between preeclamptic and healthy pregnant women. Methods: We compared oxidative and anti-oxidative system in maternal and cord blood of two groups of pair-matched mothers and neonates. Their blood malondialdehyde (MDA) and antioxidant vitamins E, A, and C were estimated and compared to evaluate if pro-oxidative status of preeclampsia differs from the status in the cord blood of pair-matched neonate. Results: MDA content in preeclamptic maternal plasma was signi'cantly higher (P < 0.001) compared to control, but its level was significantly lower in the preeclamptic cord. The concentrations of MDA were significantly lower (P < 0.001) in the cord plasma of preeclamptics compared to maternal plasma. Vitamin E concentration was lower in severely preeclamptic maternal plasma (P = 0.048). Vitamin A concentration was significantly lower (P = 0.009) in preeclamptic plasma compared to normotensive group. Interestingly, there was no significant difference between maternal and cord levels in severely preeclamptic patients. However, the cord plasma had significantly lower concentrations of vitamin A compared with those of maternal plasma. Contrary to vitamins E and A, vitamin C in the cord plasma collected from both groups showed significantly higher concentrations. Conclusions: We hypothesize that antioxidant capacity of the cord blood is sufficient, and placental barrier is adequate, to shield the fetus from oxidative injury due to increased oxidative stress of a preeclamptic mother. Thus, we conclude that the oxidative stress status is low in the blood of neonates compared to its level in the pair-matched preeclamptic mothers. Further studies are needed to explore strategies so that the normal levels of antioxidant vitamins are mai |
| مصطلحات الفهرس: | majčina krv; krv iz pupkovine; malondialdehid; antioksidacijski vitamini; trudnoća; preeklampsija, maternal plasma; cord plasma; malondialdehyde; anti-oxidant vitamins; pregnancy; preeclampsia, text, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
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| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Biochemia Medica is open access journal and all published articles are subject to CC-BY Creative Commons Attribution Licence which permits users to read, download, copy, distribute, print, search, or link to the full texts of these articles in any medium or format. Manuscript submission, article processing and publishing is free of charge and all copyrights to the manuscript are transferred to Biochemia Medica. The publisher (Croatian Society of Medical Biochemistry and Laboratory Medicine) has the right to reproduce and distribute the article in printed and electronic form. Journal is maintained and published with the financial support of the members of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) and grants given by the Republic of Croatia’s Ministry of Science and Education. All Editorial work and peer-review are maintained voluntarily. Occasionally, Biochemia Medica may publish a promotional material and advertisement in order to promote sponsorship with emphasis on the special subjects from the field of Laboratory Medicine. |
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