مورد إلكتروني
Anti-Cyanide Drugs
| العنوان: | Anti-Cyanide Drugs |
|---|---|
| المصدر: | DTIC AND NTIS |
| بيانات النشر: | 1991-06-01 |
| تفاصيل مُضافة: | HOWARD UNIV WASHINGTON DC DEPT OF CHEMISTRY Hambright, Peter |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | This report describes our efforts to develop anti-cyanide drugs using simple, water soluble metalloporphyrin molecules. Vanadium (4), chromium (3) molybdenum (5), manganese (3), iron (3), nickel (2), copper (2), silver (3), zinc, indium (3), aluminum, platinum (2), palladium (2), and gold (3) porphyrins had no affinity for cyanide at ph7.2. In vitro work showed cobalt (3), rhodium (3), and ruthenium (2) porphyrins bind cyanide in both the di- and trivalent states, from kinetic, equilibrium and electrochemical studies. Nickel (2) central N-alkyl porphyrins liberate nickel to complex with cyanide and are otherwise stable to nickel loss. sterically hindered porphyrins in the iron (III) form rapidly complex cyanide. The LD-50s of thirteen porphyrins and phthalocyanines are in the 100-600 mg/kg range in rats. None of the cobalt, iron, rhodium or silver porphyrins or phthalocyanines protect mice in a prophylactic fashion against 2 LD-50s of cyanide. |
| مصطلحات الفهرس: | Pharmacology, Organic Chemistry, ANTIDOTES, CYANIDES, CHELATING AGENTS, STABILITY, RATS, ELECTROCHEMISTRY, ORGANOMETALLIC COMPOUNDS, IN VITRO ANALYSIS, PHTHALOCYANINES, NICKEL, LOSSES, MICE, SOLUBILITY, INDIUM, RUTHENIUM, CHEMICAL WARFARE AGENTS, COBALT, PORPHYRINS, RHODIUM., CYANIDE SCAVENGERS, PE61102A, ASS11, WUDA307163, Text |
| URL: | |
| الإتاحة: | Open access content. Open access content APPROVED FOR PUBLIC RELEASE |
| ملاحظة: | text/html English |
| أرقام أخرى: | DTICE ADA239281 834243174 |
| المصدر المساهم: | From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn834243174 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |