مورد إلكتروني
Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model.
| العنوان: | Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. |
|---|---|
| المصدر: | Retrovirology, 10 |
| بيانات النشر: | 2013 |
| تفاصيل مُضافة: | Lodewick, Julie Sampaio, Carla Boxus, Mathieu Rinaldi, Anne-Sophie Coulonval, Katia Willems, Lucas Roger, Pierre P. Bex, Françoise |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Transformation by the Tax oncoprotein of the human T cell leukemia virus type 1 (HTLV-1) is governed by actions on cellular regulatory signals, including modulation of specific cellular gene expression via activation of signaling pathways, acceleration of cell cycle progression via stimulation of cyclin-dependent kinase activity leading to retinoblastoma protein (pRb) hyperphosphorylation and perturbation of survival signals. These actions control early steps in T cell transformation and development of Adult T cell leukemia (ATL), an aggressive malignancy of HTLV-1 infected T lymphocytes. Post-translational modifications of Tax by phosphorylation, ubiquitination, sumoylation and acetylation have been implicated in Tax-mediated activation of the NF-κB pathway, a key function associated with Tax transforming potential. Journal Article Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Physiologie de la régulation, Virologie médicale, Sciences bio-médicales et agricoles, Acetylation, Animals, Cell Line, Cell Transformation, Viral, Fibroblasts -- virology, Gene Products, tax -- metabolism, Histone Deacetylases -- metabolism, Human T-lymphotropic virus 1 -- pathogenicity, Humans, Lysine -- metabolism, Protein Processing, Post-Translational, Rats, p300-CBP Transcription Factors -- metabolism, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content 1 full-text file(s): info:eu-repo/semantics/openAccess |
| ملاحظة: | 1 full-text file(s): application/pdf English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/149587 uri/info:doi/10.1186/1742-4690-10-75 uri/info:pii/1742-4690-10-75 uri/info:pmid/23880157 uri/info:scp/84880334358 uri/info:pmcid/PMC3734113 https://dipot.ulb.ac.be/dspace/bitstream/2013/149587/4/doi_133758.pdf 872076682 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn872076682 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |