مورد إلكتروني
Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an in vivo model.
| العنوان: | Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an in vivo model. |
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| بيانات النشر: | 2000-01-01 |
| تفاصيل مُضافة: | Ende, M.E. (Marchina) van der Guillon, C. (Christophe) Boers, P.H.M. (Patrick) Gruters, R.A. (Rob) Racz, P. Tenner-Racz, K. Osterhaus, A.D.M.E. (Albert) Schutten, M. (Martin) |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The pathogenic properties of four primary human immunodeficiency virus type 2 (HIV-2) isolates and two primary HIV-2 biological clones were studied in an in vivo human-to-mouse chimeric model. The cell-associated viral load and the ability to reduce the severity of the induced graft-versus-host disease symptoms, the CD4/CD8 ratio and the level of repopulation of the mouse tissues by the graft, were determined. All HIV-2 strains, irrespective of their in vitro biological phenotype, replicated to high titres and significantly reduced graft-versus-host disease symptoms as well as the CD4/CD8 ratios. Reduction of graft repopulation caused by infection with the respective HIV-2 strains showed that the in vitro replication rate, syncytium-inducing capacity and ability to infect human macrophages did influence the in vivo pathogenic potential whereas broadening of coreceptor usage did not. |
| مصطلحات الفهرس: | Acute Disease, Animals, CD4-CD8 Ratio, Chimera, Disease Models, Animal, Graft vs Host Disease/immunology, HIV Infections/*etiology/immunology/virology, HIV-2/*pathogenicity/physiology, Humans, Immunohistochemistry, Leukocytes, Mononuclear/transplantation, Mice, Receptors, HIV/*physiology, Transplantation, Heterologous, Virus Replication, info:eu-repo/semantics/article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf Journal of General Virology vol. 81 no. 2, pp. 507-513 English |
| أرقام أخرى: | QGQ oai:repub.eur.nl:3710 urn:hdl:1765/3710 929966579 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn929966579 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |