مورد إلكتروني
High-definition optical coherence tomography: Contribution to the non-invasive near infrared optical imaging techniques of the skin
| العنوان: | High-definition optical coherence tomography: Contribution to the non-invasive near infrared optical imaging techniques of the skin |
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| بيانات النشر: | Universite Libre de Bruxelles university of Copenhagen, Health Science Faculty, Dermatology Université libre de Bruxelles, Faculté de Médecine – Médecine, Bruxelles 2016-07-05 |
| تفاصيل مُضافة: | Del Marmol, Véronique Jemec, Gregor B E Devière, Jacques Rorive, Sandrine Gorza, Simon-Pierre Lambert, Julien Richert, Bertrand Aubin, François F. Boone, Marc |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background. The development of non-invasive imaging techniques has been stimulated by the shortcomings of histopathology. Currently the only valid diagnostic technique in dermatology is skin biopsy which remains a painful, invasive intervention for the patient. Moreover, this approach is not always convenient for monitoring and follow-up of a skin disease. Optical imaging technologies could solve these shortcomings as they are fast, precise, repeatable and painless. There are four established non-invasive skin imaging techniques used in daily practice: dermoscopy, high-frequency ultrasound, reflectance confocal microscopy (RCM) and conventional optical coherence tomography (C-OCT). In imaging there is a trade-off between resolution and penetration depth. The former permits the visualization of cells, if the resolution is at least 3 µm. The latter enables the recognition of patterns and structures in deeper layers of the skin if the penetration depth is deeper than 150 µm. New non-invasive techniques using infrared light sources have been developed recently. The technique used in this work is a high-definition optical coherence tomography (HD-OCT).Objectives. The overall aims of this thesis were the feasibility of HD-OCT to visualize in/ex vivo, in real time and in 3-D the cellular and structural morphology of the skin, secondly the assessment of the capability of this technology to measure in vivo and real time the cutaneous optical properties, and finally the determination of the contribution of this technique to the non-invasive near-infrared imaging technologies. Five specific objectives have been established: i) could cells be observed in their 3-D microenvironment in normal and diseased skin, ii) could we describe morphologic features of cells and structures in normal and diseased skin (m_HD-OCT), iii) could these morphologic features be quantified by optical property analysis (o_HD-OCT), iv) was it possible to perform accurate thickness measurements in normal Doctorat en Sciences médicales (Santé Publique) info:eu-repo/semantics/nonPublished |
| مصطلحات الفهرس: | Dermatologie, Anatomopathologie, Cancérologie, Allergie et immunopathologie, Gériatrie - gérontologie, High-definition optical coherence tomography, Reflectance confocal microscopy, Conventional optical coherence tomography, Dermoscopy, Near infrared, Non-invasive imaging, Melanoma, Non melanoma skin cancer, Optical properties, Skin ageing, Inflammation, Human acellular dermal matrices, info:eu-repo/semantics/doctoralThesis, info:ulb-repo/semantics/doctoralThesis, info:ulb-repo/semantics/openurl/vlink-dissertation |
| URL: | |
| الإتاحة: | Open access content. Open access content 3 full-text file(s): info:eu-repo/semantics/openAccess | info:eu-repo/semantics/restrictedAccess | info:eu-repo/semantics/closedAccess |
| ملاحظة: | 1 v. (492 p.) 3 full-text file(s): application/vnd.openxmlformats-officedocument.wordprocessingml.document | application/pdf | application/pdf English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/232235 uri/urn:isbn:978-909-029-815-3 961110923 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn961110923 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |