Investigating the inhibition of cytochrome P450 isoform 1A1 by açai berry (Euterpe oleracea) extracts using a bioassay guided fractionation approach
| العنوان: | Investigating the inhibition of cytochrome P450 isoform 1A1 by açai berry (Euterpe oleracea) extracts using a bioassay guided fractionation approach |
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| المؤلفون: | Collins, Davis Earl. |
| بيانات النشر: | [Greensboro, N.C.] : [University of North Carolina at Greensboro], [2016] |
| تفاصيل مُضافة: | NC Digital Online Collection of Knowledge and Scholarship (NCDOCKS) |
| وصف مادي: | ix, 90 pages : illustrations, digital, PDF file 1.86 MB. |
| Supplemental Data: | System requirements: PC, World Wide Web browser, PDF reader. Available online via NCDOCKS. Mode of access: World Wide Web. |
| مستخلص: | "Xenobiotic metabolism is an important process within the human body, as it alters large, foreign, hydrophobic molecules and prepares them for excretion. This process is largely carried out in the liver and is accomplished by a superfamily of heme-containing enzymes, termed the Cytochrome P450's. Each individual P450 has a certain specificity for the substrates it may metabolize, but these enzymes are non-selective in nature and may catalyze the metabolism of a wide variety of substrates. Due to this characteristic of P450 - mediated metabolism, pharmaceuticals when taken concomitantly may possibly interfere with one another's metabolism, which can lead to adverse drug reactions. This can also be true for natural product constituents that have been consumed as a part of one's dietary intake. Consumption of the acai berry (Euterpe oleracea) has grown quite rapidly in recent years as it contains a high concentration of antioxidant molecules, and has also been marketed as a weight loss supplement. Although it appears to benefit one's health and longevity, the acai berry has not been characterized in terms of its effect on P450 - mediated metabolism. Utilizing an activity guided fractionation scheme, acai berry extracts were assayed in CYP1A1 and CYP1A2 enzyme reactions to determine constituents responsible for enzyme inhibition."--Abstract from author supplied metadata. |
| الموضوعات: | Cytochrome P-450 Inhibitors., Enzyme inhibitors., Açaí palm., Cytochrome P-450 Inhibiteurs., Antienzymes., Açaí palm, Enzyme inhibitors |
| مصطلحات الفهرس: | dissertations., Academic theses, Academic theses., Thèses et écrits académiques. |
| URL: | |
| ملاحظة: | Title from PDF title page (viewed Aug. 16, 2017). Directed by Gregory M. Raner ; submitted to the Dept. of Chemistry and Biochemistry. Includes bibliographical references (pages 83-90). |
| أرقام أخرى: | NGU oai:libres.uncg.edu/19552 979987371 |
| المصدر المساهم: | From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn979987371 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |