مورد إلكتروني
ASPIRINSKA REZISTENCIJA
| العنوان: | ASPIRINSKA REZISTENCIJA |
|---|---|
| عناروين إضافية: | ASPIRIN RESISTANCE |
| المصدر: | Liječnički vjesnik; ISSN 0024-3477 (Print); ISSN 1849-2177 (Online); Volume 133; Issue 9-10 |
| بيانات النشر: | Croatian medical association 2011 |
| تفاصيل مُضافة: | Davor Miličić Boško Skorić |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Iako je acetilsalicilna kiselina u farmakoterapiji prisutna već više od 100 godina, i dalje je kamen temeljac primarne i sekundarne prevencije u kardiovaskularnih bolesnika. Unatoč nedvojbenoj koristi od njezine uporabe, u jednog dijela liječenih ipak će doći do nepovoljnih aterotrombotskih manifestacija poput tromboze u stentu, infarkta miokarda, moždanog udara ili kardiovaskularne smrti. Posljednjih godina sve je više znanstvenog interesa usmjereno na ispitivanje povezanosti ovih događaja s laboratorijskim dokazom slabijeg antitrombocitnog učinka acetilsalicilne kiseline, što je i dovelo do nastanka koncepta tzv. aspirinske rezistencije. Osim nedostatka zajedničke definicije ove pojave, važan je problem u njezinu istraživanju i velik broj različitih te slabo standardiziranih laboratorijskih metoda. Unatoč velikom broju objavljenih studija koje govore u prilog njezinoj kliničkoj važnosti, još ne postoje preporuke struke o potrebi rutinskog testiranja bolesnika na aspirinsku rezistenciju, kao ni prilagođavanja doza ili vrste antiagregacijskih lijekova u slučaju pozitivnog nalaza. Although present in pharmacotherapy for more than 100 years, aspirin still represents a cornerstone in the primary and secondary prevention of cardiovascular patients. Despite undoubtful benefit, a certain proportion of patients treated with aspirin develops adverse atherothrombotic events like stent thrombosis, myocardial infarction, stroke and cardiovascular death. In recent years, there is a growing scientific interest concerning the relationship of suboptimal antiplatelet response to aspirin and cardiovascular prognosis that has led to the concept of »aspirin resistance«. Besides the absence of uniform definition of aspirin resistance, an important issue in these studies are numerous and poorly standardized laboratory methods that are used in its detection. Despite an increasing number of reports that favour its clinical significance, there are still no expert recommendations for routine assessment of platelet aggregation as well as for modification of antiplatelet doses or regimens in the case of established aspirin resistance. |
| مصطلحات الفهرس: | Aspirin – terapijska primjena, farmakologija; Otpornost na lijekove; Inhibitori agregacije trombocita – terapijska primjena, farmakologija; Inhibitori ciklooksigenaze – terapijska primjena; Trombociti – djelovanje lijeka, fiziologija; Testovi funkcije trombocita – metode; Kardiovaskularne bolesti – farmakoterapija, komplikacije; Tromboza – prevencija, Aspirin – therapeutic use, pharmacology; Drug resistance; Platelet aggregation inhibitors – therapeutic use, pharmacology; Cyclooxygenase inhibitors – therapeutic use; Blood platelets – drug effects, physiology; Platelet function tests – methods; Cardiovascular diseases – drug therapy, complications; Thrombosis – prevention and control, text, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess The Medical Journal is an open access journal. The content of the magazine is available in its entirety free of charge. The contents of the Medical Journal may be reproduced with the quotation "taken from the Medical Journal". Users may not use the materials for commercial purposes, may not modify, redesign or rework the material. |
| ملاحظة: | application/pdf Croatian |
| أرقام أخرى: | HRCAK oai:hrcak.srce.hr:171855 985175373 |
| المصدر المساهم: | HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn985175373 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |