مورد إلكتروني
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
| العنوان: | Beta-catenin is dispensable for hematopoiesis and lymphopoiesis |
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| بيانات النشر: | 2004 |
| تفاصيل مُضافة: | Cobas, M. Wilson, A. Ernst, B. Mancini, S. J. MacDonald, H. R. Kemler, R. Radtke, F. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis. |
| مصطلحات الفهرس: | Animals, B-Lymphocytes/cytology/immunology, Cell Differentiation, Cell Division, Chimera, Cytoskeletal Proteins/deficiency/genetics/*physiology, Female, Hematopoiesis/genetics/*physiology, Integrases/genetics, Lymphopoiesis/genetics/*physiology, Mice, Inbred C57BL, Knockout, Phenotype, Proto-Oncogene Proteins/genetics/physiology, Research Support, Non-U.S. Gov't, Signal Transduction, T-Lymphocytes/cytology/immunology, Trans-Activators/deficiency/genetics/*physiology, Wnt Proteins, beta Catenin, Text |
| DOI: | 10.1084.jem.20031615 |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | text/html English |
| أرقام أخرى: | SWFDL oai:infoscience.epfl.ch:97248 doi:10.1084/jem.20031615 999711320 |
| المصدر المساهم: | ECOLE POLYTECHNIC FEDERALE DE LAUSANNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn999711320 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1084.jem.20031615 |
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