مورد إلكتروني
Cardioprotection and lifespan extension by the natural polyamine spermidine
| العنوان: | Cardioprotection and lifespan extension by the natural polyamine spermidine |
|---|---|
| بيانات النشر: | Nature Medicine 2016-11-14 |
| تفاصيل مُضافة: | Eisenberg, Tobias Abdellatif, Mahmoud Schroeder, Sabrina Primessnig, Uwe Stekovic, Slaven Pendl, Tobias Harger, Alexandra Schipke, Julia Zimmermann, Andreas Schmidt, Albrecht Tong, Mingming Ruckenstuhl, Christoph Dammbrueck, Christopher Gross, Angelina S Herbst, Viktoria Magnes, Christoph Trausinger, Gert Narath, Sophie Meinitzer, Andreas Hu, Zehan Kirsch, Alexander Eller, Kathrin Carmona-Gutierrez, Didac Büttner, Sabrina Pietrocola, Federico Knittelfelder, Oskar Schrepfer, Emilie Rockenfeller, Patrick Simonini, Corinna Rahn, Alexandros Horsch, Marion Moreth, Kristin Beckers, Johannes Fuchs, Helmut Gailus-Durner, Valerie Neff, Frauke Janik, Dirk Rathkolb, Birgit Rozman, Jan de Angelis, Martin Hrabe Moustafa, Tarek Haemmerle, Guenter Mayr, Manuel Willeit, Peter von Frieling-Salewsky, Marion Pieske, Burkert Scorrano, Luca Pieber, Thomas Pechlaner, Raimund Willeit, Johann Sigrist, Stephan J Linke, Wolfgang A Mühlfeld, Christian Sadoshima, Junichi Dengjel, Joern Kiechl, Stefan Kroemer, Guido Sedej, Simon Madeo, Frank |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease. |
| مصطلحات الفهرس: | Q Science, QP Physiology (Living systems), QP506 Molecular biology, QP517 Biochemistry, R Medicine, RC Internal medicine, RC667 Diseases of the circulatory (cardiovascular) system, Article, PeerReviewed |
| URL: | doi:10.1038/nm.4222 |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | application/vnd.openxmlformats-officedocument.wordprocessingml.document application/pdf Cardioprotection and lifespan extension by the natural polyamine spermidine English English |
| أرقام أخرى: | TUI oai:kar.kent.ac.uk:58741 https://kar.kent.ac.uk/58741/1/Cardioprotection%20and%20lifespan%20extension%20by%20the%20natural%20polyamine%20spermid....docx https://kar.kent.ac.uk/58741/3/NM.4222_authors%20manuscript.pdf Eisenberg, Tobias, Abdellatif, Mahmoud, Schroeder, Sabrina, Primessnig, Uwe, Stekovic, Slaven, Pendl, Tobias, Harger, Alexandra, Schipke, Julia, Zimmermann, Andreas, Schmidt, Albrecht, and others. Tong, Mingming, Ruckenstuhl, Christoph, Dammbrueck, Christopher, Gross, Angelina S, Herbst, Viktoria, Magnes, Christoph, Trausinger, Gert, Narath, Sophie, Meinitzer, Andreas, Hu, Zehan, Kirsch, Alexander, Eller, Kathrin, Carmona-Gutierrez, Didac, Büttner, Sabrina, Pietrocola, Federico, Knittelfelder, Oskar, Schrepfer, Emilie, Rockenfeller, Patrick, Simonini, Corinna, Rahn, Alexandros, Horsch, Marion, Moreth, Kristin, Beckers, Johannes, Fuchs, Helmut, Gailus-Durner, Valerie, Neff, Frauke, Janik, Dirk, Rathkolb, Birgit, Rozman, Jan, de Angelis, Martin Hrabe, Moustafa, Tarek, Haemmerle, Guenter, Mayr, Manuel, Willeit, Peter, von Frieling-Salewsky, Marion, Pieske, Burkert, Scorrano, Luca, Pieber, Thomas, Pechlaner, Raimund, Willeit, Johann, Sigrist, Stephan J, Linke, Wolfgang A, Mühlfeld, Christian, Sadoshima, Junichi, Dengjel, Joern, Kiechl, Stefan, Kroemer, Guido, Sedej, Simon, and Madeo, Frank (hide) (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, (22). pp. 1428-1438. ISSN 1078-8956. (doi:10.1038/nm.4222 <https://doi.org/10.1038/nm.4222>) (KAR id:58741 ) 1080457055 |
| المصدر المساهم: | NATIONAL CHIAO TUNG UNIV From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1080457055 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |