مورد إلكتروني
Factors Impacting Treatment Choice in the First-Line Treatment of Colorectal Cancer
| العنوان: | Factors Impacting Treatment Choice in the First-Line Treatment of Colorectal Cancer |
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| المؤلفون: | Bloem, LT, De Abreu Lourenço, R, Chin, M, Ly, B, Haas, M |
| بيانات النشر: | Springer 2016-05-11 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | IntroductionTo investigate the factors that affect the choice of 5-fluorouracil (5-FU) or its oral alternative, capecitabine, as first-line treatment in patients with colorectal cancer (CRC).MethodsPatients treated with 5-FU or capecitabine for CRC between January 1, 2011 and December 31, 2013 in a teaching hospital in the Sydney metropolitan area, Australia were identified using the hospital’s database MOSAIQ®. The electronic medical record of each patient was manually reviewed to extract factors potentially affecting treatment choice. Logistic regression was used to assess which patient and/or treatment factors could explain the choice between 5-FU or capecitabine. Where it was available in the medical correspondence, the explicit reason for the choice made was extracted.Results170 CRC patients were included; 119 on 5-FU, and 51 on capecitabine. The odds of receiving capecitabine as a first-line treatment were positively associated with giving patients a choice in the decision (OR = 17.51, 95% CI: 5.37–57.08). Qualitative data suggest treatment choices were motivated by convenience (oral administration) and tolerability. Time from diagnosis to treatment commencement (OR = 1.02 per month, 95% CI 1.00–1.04) was also found to be positively associated with the choice of capecitabine. The odds of being treated with capecitabine were lower for patients who lived further from the treating hospital (OR = 0.22, 95% CI 0.05–0.94).ConclusionThis study suggests that patient choice, favoring oral capecitabine over i.v. 5-FU, was a key factor influencing first-line treatment for CRC in this cohort. To respect their autonomy, patients should be involved in the clinical decision making process. |
| مصطلحات الفهرس: | colorectal cancer, mode of administration, patient involvement, treatment choice, text, Journal Article, Article |
| URL: | Oncology and Therapy, 4, 1, 103-116 |
| الإتاحة: | Open access content. Open access content This article has been accepted for publication in Oncology and Therapy ©: 2016 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved. free_to_read |
| أرقام أخرى: | LJ1 oai:unsworks.library.unsw.edu.au:1959.4/unsworks_59903 10.1007/s40487-016-0020-4 urn:issn:2366-1070 urn:issn:2366-1089 1111916196 |
| المصدر المساهم: | UNIV OF NEW S WALES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1111916196 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |