مورد إلكتروني
P450BM3-Catalyzed oxidations employing dual functional small molecules
| العنوان: | P450BM3-Catalyzed oxidations employing dual functional small molecules |
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| بيانات النشر: | 2019 |
| تفاصيل مُضافة: | Willot, S.J. (author) Tieves, F. (author) Girhard, Marco (author) Urlacher, Vlada B. (author) Hollmann, F. (author) De Gonzalo, G. (author) |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation reactions. These DFSMs enhance P450BM3 activity with hydrogen peroxide as an oxidant, converting these enzymes into formal peroxygenases. This system has been employed for the catalytic epoxidation of styrene and in the sulfoxidation of thioanisole. Various P450BM3 variants have been evaluated in terms of activity and selectivity of the peroxygenase reactions. BT/Biocatalysis |
| مصطلحات الفهرس: | Biocatalysis, Cytochrome P450, Dual functional small molecules, Epoxidations, Sulfoxidation, journal article |
| DOI: | 10.3390.catal9070567 |
| URL: | Catalysts--2073-4344--06aac578-d8aa-4449-9a10-70f5ab4660cd |
| الإتاحة: | Open access content. Open access content © 2019 S.J. Willot, F. Tieves, Marco Girhard, Vlada B. Urlacher, F. Hollmann, G. De Gonzalo |
| ملاحظة: | English |
| أرقام أخرى: | NLTUD oai:tudelft.nl:uuid:53df8061-0bdd-4e24-97e9-ebe23f2a47f1 doi:10.3390/catal9070567 1122778279 |
| المصدر المساهم: | DELFT UNIV OF TECHNOL From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1122778279 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.3390.catal9070567 |
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