مورد إلكتروني
Bage - a New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-lymphocytes
| العنوان: | Bage - a New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-lymphocytes |
|---|---|
| المؤلفون: | UCL - MED - Sciences médicales, Boël, P., Wildmann, C., Sensi, ML., Brasseur, R., Renauld, Jean-Christophe, Coulie, Pierre, Boon, Thierry, van der Bruggen, Pierre |
| المصدر: | Immunity, Vol. 2, no. 2, p. 167-175 (1995) |
| بيانات النشر: | Cell Press 1995 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named SAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw*1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy. |
| مصطلحات الفهرس: | info:eu-repo/semantics/article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UCDLC oai:dial.uclouvain.be:boreal:48238 boreal:48238 info:doi/10.1016/S1074-7613(95)80053-0 urn:ISSN:1074-7613 urn:EISSN:1097-4180 1130560493 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1130560493 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |