مورد إلكتروني
A novel glucokinase activator modulates pancreatic islet and hepatocyte function
| العنوان: | A novel glucokinase activator modulates pancreatic islet and hepatocyte function |
|---|---|
| المؤلفون: | UCL, Efanov, AM, Barrett, DG, Brenner, MB, Briggs, SL, Delaunois, A., Durbin, JD, Giese, U, Guo, HH, Radloff, M, Gil, GS, Sewing, S, Wang, Y, Weichert, A, Zaliani, A, Gromada, J |
| المصدر: | Endocrinology, Vol. 146, no. 9, p. 3696-3701 (2005) |
| بيانات النشر: | Endocrine Soc 2005 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report here the effects of a novel glucokinase activator, LY2121260. The activator enhanced GK activity via binding to the allosteric site located in the hinge region of the enzyme. LY2121260 stimulated insulin secretion in a glucose-dependent manner in pancreatic beta-cells and increased glucose use in rat hepatocytes. In addition, incubation of beta-cells with the GK activator resulted in increased GK protein levels, suggesting that enhanced insulin secretion on chronic treatment with a GK activator may be due to not only changed enzyme kinetics but also elevated enzyme levels. Animals treated with LY2121260 showed an improved glucose tolerance after oral glucose challenge. These results support the concept that GK activators represent a new class of compounds that increase both insulin secretion and hepatic glucose use and in doing so may prove to be effective agents for the control of blood glucose levels in patients with type 2 diabetes. |
| مصطلحات الفهرس: | info:eu-repo/semantics/article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | UCDLC oai:dial.uclouvain.be:boreal:39110 boreal:39110 info:doi/10.1210/en.2005-0377 urn:ISSN:0013-7227 urn:EISSN:1945-7170 1130567005 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1130567005 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |