مورد إلكتروني
Can better management of periodontal disease delay the onset and progression of Alzheimer’s disease?
| العنوان: | Can better management of periodontal disease delay the onset and progression of Alzheimer’s disease? |
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| بيانات النشر: | IOS Press 2017-05-11 |
| تفاصيل مُضافة: | Harding, Alice Robinson, Sarita Jane Crean, Stjohn Singhrao, Simarjit Kaur |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | A risk factor relationship exists between periodontal disease and Alzheimer’s disease (AD) via tooth loss, and improved memory following dental intervention. This links the microbial contribution from indigenous oral periodontal pathogens to the manifestation of chronic conditions, such as AD. Here, we use Porphyromonas gingivalis infection to illustrate its effect on mental health. P. gingivalis infection, in its primary sub-gingival niche, can cause polymicrobial synergy and dysbiosis. Dysbiosis describes the residency of select commensals from the oral cavity following co-aggregation around the dominant keystone pathogen, such as P. gingivalis, to gain greater virulence. The initial process involves P. gingivalis disturbing neutrophil mediated innate immune responses in the healthy gingivae and then downregulating adaptive immune cell differentiation and development to invade, and subsequently, establish new dysbiotic bacterial communities. Immune responses affect the host in general and functionally via dietary adjustments caused by tooth loss. Studies from animals orally infected with P. gingivalis confirm this bacterium can transmigrate to distant organ sites (the brain) and contribute towards peripheral and intracerebral inflammation, and compromise vascular and microvascular integrity. In another study, P. gingivalis infection caused sleep pattern disturbances by altering glial cell light/dark molecular clock activity, and this, in turn, can affect the clearance of danger associated molecular patterns, such as amyloid-beta, via the glymphatic system. Since, P. gingivalis can transmigrate to the brain, and modulate organ-specific inflammatory innate and adaptive immune responses, this paper explores whether better management of indigenous periodontal bacteria could delay/prevent the onset and/or progression of dementia. |
| مصطلحات الفهرس: | A900 - Others in medicine & dentistry, B132 - Pathobiology, Article, PeerReviewed |
| URL: | |
| الإتاحة: | Open access content. Open access content cc_by_nc_4 |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | UKLAN oai:clok.uclan.ac.uk:17325 Harding, Alice, Robinson, Sarita Jane ORCID: 0000-0002-4237-5412 <http://orcid.org/0000-0002-4237-5412>, Crean, Stjohn ORCID: 0000-0001-9336-8549 <http://orcid.org/0000-0001-9336-8549> and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 <http://orcid.org/0000-0001-9573-5963> (2017) Can better management of periodontal disease delay the onset and progression of Alzheimer’s disease? Journal of Alzheimer’s Disease, 58 (2). pp. 337-348. ISSN 1387-2877 1137481796 |
| المصدر المساهم: | UNIV OF CENT LANCASHIRE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1137481796 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |