مورد إلكتروني
Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity
| العنوان: | Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity |
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| بيانات النشر: | Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience Arts and Science Neuroscience 2020 |
| تفاصيل مُضافة: | McDonald, Robert J. Fraser, Ellen University of Lethbridge. Faculty of Arts and Science |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward. |
| مصطلحات الفهرس: | Brain plasticity and reorganization, Cognition, Developmental neurobiology, Long-term Potentiation, Neural circuitry -- Adaptation, Neuroplasticity, Thesis |
| URL: | Thesis (University of Lethbridge. Faculty of Arts and Science) |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | en_US |
| أرقام أخرى: | CN4UL oai:opus.uleth.ca:10133/5753 https://hdl.handle.net/10133/5753 1196044993 |
| المصدر المساهم: | UNIV OF LETHBRIDGE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1196044993 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |