مورد إلكتروني
VMAT vs eight field IMRT: dosimetric comparison of pelvic radiotherapy for patients with high-risk prostate cancer in terms of bone marrow sparing
| العنوان: | VMAT vs eight field IMRT: dosimetric comparison of pelvic radiotherapy for patients with high-risk prostate cancer in terms of bone marrow sparing |
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| المصدر: | Turkish Journal of Oncology / Türk Onkoloji Dergisi |
| بيانات النشر: | Kare Yayıncılık National 2019 |
| تفاصيل مُضافة: | Sezen, Duygu; Alpan, Vildan; Bölükbaşı, Yasemin (ORCID 0000-0002-3170-5826 & YÖK ID 216814); Sağlam, Yücel; Selek, Uğur (ORCID 0000-0001-8087-3140 & YÖK ID 27211) Koç University Hospital School of Medicine Department of Radiation Oncology |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objective: although there is no complete consensus on elective pelvic nodal irradiation for patients with - risk prostate cancer, pelvic radiotherapy with androgen ablation has been more commonly used in many centers. An important part of bone marrow (BM) reserve remains in the pelvic radiation treatment field. This study aimed to evaluate and compare the intensity modulated (step-and-shoot IMRT: ssIMRT) and volumetric modulated arc radiotherapy (VMAT) techniques for pelvic radiotherapy in terms of pelvic BM doses. Methods: this study was based on the simulation scan data of 10 patients with prostate cancer as 3-mm slice thickness using a full bladder and rectal balloon. The first phase of the treatment planning prescribed to pelvic lymphatic (46 Gy/2 Gy/fraction). The second phase consisted of the seminal vesicles and prostate (32 Gy/2 Gy/fraction). The PTV margin was 0.4 cm posteriorly due to rectum and 0.6 cm in all other (including PTVlymphatic) directions. Using same target volumes, ssIMR'l with eight angles (225 degrees, 260 degrees, 295 degrees, 330 degrees, 30 degrees, 65 degrees, 100 degrees, 135 degrees) and double arc (182 degrees, -178 degrees arc angle) VMAT were planned for each patient data set. The planning objective was to cover the PTV by at least 95% of the prescribed isodose and CTV by 98% of the prescribed isodose line. No special dose constraint was given for BM sparing. Each technique was compared by using dose volume histograms (DVH) of V5, V10, V20, V30, V40 of the sacral BM (SBM), iliac BM (IBM), and ischium, pubis, and proximal femora (lower pelvis) and femoral BM (IBM). In addition, V20 V30, V40, and V70 for bladder, and V30, V40, V76, and V80 for the rectum, homogeneity index and the monitor units (MU) were evaluated. The two-sided Wilcoxon's test was used for statistical analysis (p<0.05). Results: for the same PTV coverage, VMAT and ssIMRT plans had similar dose distributions for FBM, IBM, SBM, and total BM as well as the other critica NA |
| مصطلحات الفهرس: | Oncology, BM; Intensity modulated radiotherapy; Prostate; Pelvic; Radiotherapy; Volumetric arc radiotherapy, Journal article, text/academic publication |
| URL: | Publisher version Koç University Institutional Repository |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | pdf English |
| أرقام أخرى: | T9K oai:libdigitalcollections.ku.edu.tr:IR/8448 1300-7467 Alpan, V, Y Bolukbasi, Y Saglam, U Selek, and D Sezen. "Vmat Vs Eight Field Imrt: Dosimetric Comparison of Pelvic Radiotherapy for Patients with High-Risk Prostate Cancer in Terms of Bone Marrow Sparing." Turk Onkoloji Dergisi. 34.3 (2019): 37-44. IR01818.pdf WoS; Scopus NA NA 1200731311 |
| المصدر المساهم: | KOC UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1200731311 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |