مورد إلكتروني
The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling
| العنوان: | The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling |
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| المؤلفون: | Schaap, Pauline, Barrantes, Israel, Minx, Pat, Sasaki, Narie, Anderson, Roger W., Beinard, Marianne, Biggar, Kyle K., Buehler, Nicolas E., Bundschuh, Ralf, Chen, Xiao, Fronick, Catrina, Fulton, Lucinda, Golderer, Georg, Jahn, Niels, Knoop, Volker, Landweber, Laura F., Maric, Chrystelle, Miller, Dennis, Noegel, Angelika A., Peace, Rob, Pierron, Gerard, Sasaki, Taeko, Schallenberg-Ruedinger, Mareike, Schleicher, Michael, Singh, Reema, Spaller, Thomas, Storey, Kenneth B., Suzuki, Takamasa, Tomlinson, Chad, Tyson, John J., Warren, Wesley C., Werner, Ernst R., Werner-Felmayer, Gabriele, Wilson, Richard K., Winckler, Thomas, Gott, Jonatha M., Gloeckner, Gernot, Marwan, Wolfgang |
| بيانات النشر: | OXFORD UNIV PRESS 2016 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Physarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms. It has a sophisticated life cycle with several distinct stages including amoebal, flagellated, and plasmodial cells. It is unusual in switching between open and closed mitosis according to specific life-cycle stages. Here we present the analysis of the genome of this enigmatic and important model organism and compare it with closely related species. The genome is littered with simple and complex repeats and the coding regions are frequently interrupted by introns with a mean size of 100 bases. Complemented with extensive transcriptome data, we define approximately 31,000 gene loci, providing unexpected insights into early eukaryote evolution. We describe extensive use of histidine kinase-based two-component systems and tyrosine kinase signaling, the presence of bacterial and plant type photoreceptors (phytochromes, cryptochrome, and phototropin) and of plant-type pentatricopeptide repeat proteins, as well as metabolic pathways, and a cell cycle control system typically found in more complex eukaryotes. Our analysis characterizes P. polycephalum as a prototypical eukaryote with features attributed to the last common ancestor of Amorphea, that is, the Amoebozoa and Opisthokonts. Specifically, the presence of tyrosine kinases in Acanthamoeba and Physarum as representatives of two distantly related subdivisions of Amoebozoa argues against the later emergence of tyrosine kinase signaling in the opisthokont lineage and also against the acquisition by horizontal gene transfer. |
| مصطلحات الفهرس: | ddc:no, doc-type:article, publishedVersion |
| URL: | 10.1093/gbe/evv237 |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | K7U oai:USBKOELN.ub.uni-koeln.de:29274 Schaap, Pauline ORCID: 0000-0003-4500-2555 <https://orcid.org/0000-0003-4500-2555>, Barrantes, Israel, Minx, Pat, Sasaki, Narie, Anderson, Roger W., Beinard, Marianne, Biggar, Kyle K., Buehler, Nicolas E., Bundschuh, Ralf, Chen, Xiao, Fronick, Catrina, Fulton, Lucinda, Golderer, Georg, Jahn, Niels, Knoop, Volker, Landweber, Laura F., Maric, Chrystelle, Miller, Dennis, Noegel, Angelika A., Peace, Rob, Pierron, Gerard, Sasaki, Taeko, Schallenberg-Ruedinger, Mareike, Schleicher, Michael, Singh, Reema, Spaller, Thomas, Storey, Kenneth B., Suzuki, Takamasa, Tomlinson, Chad, Tyson, John J., Warren, Wesley C., Werner, Ernst R. ORCID: 0000-0003-1948-3391 <https://orcid.org/0000-0003-1948-3391>, Werner-Felmayer, Gabriele ORCID: 0000-0002-2340-8063 <https://orcid.org/0000-0002-2340-8063>, Wilson, Richard K. ORCID: 0000-0002-1992-1358 <https://orcid.org/0000-0002-1992-1358>, Winckler, Thomas, Gott, Jonatha M., Gloeckner, Gernot and Marwan, Wolfgang (2016). The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling. Genome Biol. Evol., 8 (1). S. 109 - 126. OXFORD: OXFORD UNIV PRESS. ISSN 1759-6653 1223535872 |
| المصدر المساهم: | UNIVERSITATS- UND STADTBIBLIOTHEK KOLN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1223535872 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |