مورد إلكتروني
Influence of comorbid heart disease on dyspnea and health status in patients with COPD - a cohort study
| العنوان: | Influence of comorbid heart disease on dyspnea and health status in patients with COPD - a cohort study |
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| بيانات النشر: | Uppsala universitet, Allmänmedicin och preventivmedicin Uppsala universitet, Lung- allergi- och sömnforskning Orebro Univ, Sch Med Sci, Orebro, Sweden;Cty Council Varmland, Ctr Clin Res, Karlstad, Sweden Orebro Univ, Sch Med Sci, Orebro, Sweden Orebro Univ, Clin Epidemiol & Biostat, Orebro, Sweden;Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden;UCL, Dept Epidemiol & Publ Hlth, London, England Orebro Univ, Sch Med Sci, Dept Resp Med, Orebro, Sweden DOVE MEDICAL PRESS LTD 2018 |
| تفاصيل مُضافة: | Giezeman, Maaike Hasselgren, Mikael Lisspers, Karin Ställberg, Björn Montgomery, Scott Janson, Christer Sundh, Josefin |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Purpose: The aim of this study was to examine the changing influence over time of comorbid heart disease on symptoms and health status in patients with COPD. Patients and methods: This is a prospective cohort study of 495 COPD patients with a baseline in 2005 and follow-up in 2012. The study population was divided into three groups: patients without heart disease (no-HD), those diagnosed with heart disease during the study period (new-HD) and those with heart disease at baseline (HD). Symptoms were measured using the mMRC. Health status was measured using the Clinical COPD Questionnaire (CCQ) and the COPD Assessment Test (CAT; only available in 2012). Logistic regression with mMRC $2 and linear regression with CCQ and CAT scores in 2012 as dependent variables were performed unadjusted, adjusted for potential confounders, and additionally adjusted for baseline mMRC, respectively, CCQ scores. Results: Mean mMRC worsened from 2005 to 2012 as follows: for the no-HD group from 1.8 (+/- 1.3) to 2.0 (+/- 1.4), (P=0.003), for new-HD from 2.2 (+/- 1.3) to 2.4 (+/- 1.4), (P=0.16), and for HD from 2.2 (+/- 1.3) to 2.5 (+/- 1.4), (P=0.03). In logistic regression adjusted for potential confounding factors, HD (OR 1.71; 95% CI: 1.03-2.86) was associated with mMRC $ 2. Health status worsened from mean CCQ as follows: for no-HD from 1.9 (+/- 1.2) to 2.1 (+/- 1.3) with (P=0.01), for new-HD from 2.3 (+/- 1.5) to 2.6 (+/- 1.6) with (P=0.07), and for HD from 2.4 (+/- 1.1) to 2.5 (+/- 1.2) with (P=0.57). In linear regression adjusted for potential confounders, HD (regression coefficient 0.12; 95% CI: 0.04-5.91) and new-HD (0.15; 0.89-5.92) were associated with higher CAT scores. In CCQ functional state domain, new-HD (0.14; 0.18-1.16) and HD (0.12; 0.04-0.92) were associated with higher scores. After additional correction for baseline mMRC and CCQ, no statistically significant associations were found. Conclusion: Heart disease contributes to lower health status and higher symptom burden |
| مصطلحات الفهرس: | COPD Assessment Test, CAT, Clinical COPD Questionnaire, CCQ, modified Medical Research Council dyspnea score, mMRC, ischemic heart disease, heart failure, Respiratory Medicine and Allergy, Lungmedicin och allergi, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.2147.COPD.S175641 |
| URL: | The International Journal of Chronic Obstructive Pulmonary Disease, 1176-9106, 2018, 13, s. 3857-3865 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | UPE oai:DiVA.org:uu-372686 0000-0001-8497-7326 0000-0001-5093-6980 doi:10.2147/COPD.S175641 ISI:000452171700001 1233878293 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1233878293 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.2147.COPD.S175641 |
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