مورد إلكتروني
Cognitive test results are associated with mortality and rehospitalization in heart failure: Swedish prospective cohort study
| العنوان: | Cognitive test results are associated with mortality and rehospitalization in heart failure: Swedish prospective cohort study |
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| بيانات النشر: | Linköpings universitet, Avdelningen för prevention, rehabilitering och nära vård Linköpings universitet, Medicinska fakulteten Region Östergötland, Medicinska och geriatriska akutkliniken Lund Univ, Sweden; Skane Univ Hosp, Sweden Lund Univ, Sweden Lund Univ, Sweden Lund Univ, Sweden Lund Univ, Sweden Lund Univ, Sweden; Skane Univ Hosp, Sweden Lund Univ, Sweden Lund Univ, Sweden; Skane Univ Hosp, Sweden Lund Univ, Sweden Lund Univ, Sweden; Skane Univ Hosp, Sweden WILEY PERIODICALS, INC 2020 |
| تفاصيل مُضافة: | Holm, Hannes Bachus, Erasmus Jujic, Amra Nilsson, Erik D. Wadstrom, Benjamin Molvin, John Minthon, Lennart Fedorowski, Artur Nägga, Katarina Magnusson, Martin |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Aims We aimed to search for associations between cognitive test results with mortality and rehospitalization in a Swedish prospective heart failure (HF) patient cohort. Methods and results Two hundred and eighty-one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making Test A, and Symbol Digit Modalities Test. The mean follow-up time censored at rehospitalization or death was 13 months (interquartile range, 14) and 28 months (interquartile range, 29), respectively. Relations between cognitive test results, mortality, and rehospitalization risk were analysed using multivariable Cox regression model adjusted for age, sex, body mass index, systolic blood pressure, atrial fibrillation, diabetes, smoking, educational level, New York Heart Association class, and prior cardiovascular disease. A total of 80 patients (29%) had signs of cognitive impairment (MoCA score < 23 points). In the fully adjusted Cox regression model using standardized values per 1 SD change of each cognitive test, lower score on MoCA [hazard ratio (HR), 0.75; confidence interval (CI), 0.60-0.95;P = 0.016] and Symbol Digit Modalities Test (HR, 0.66; CI, 0.48-0.90;P = 0.008) yielded significant associations with increased mortality. Rehospitalization risk (n = 173; 62%) was significantly associated with lower MoCA score (HR, 0.84; CI, 0.71-0.99;P = 0.033). Conclusions Two included cognitive tests were associated with mortality in hospitalized HF patients, independently of traditional risk factors. In addition, worse cognitive test scores on MoCA heralded increased risk of rehospitalization. Funding Agencies|Medical Faculty of Lund University; Skane University Hospital; Crafoord Foundation; Ernhold Lundstroms Research Foundation; Region Skane; Hulda and Conrad Mossfelt Foundation; Southwest Skanes Diabetes Foundation; Kockska Foundation; Research Funds of Region Skane; Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation; Wallenberg Center for Molecular Medicine, Lund University |
| مصطلحات الفهرس: | Cognitive dysfunction; Heart failure; Mortality; Rehospitalization, Cardiac and Cardiovascular Systems, Kardiologi, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1002.ehf2.12909 |
| URL: | ESC Heart Failure, 2020, 7:5, s. 2948-2955 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | UPE oai:DiVA.org:liu-169335 0000-0003-0194-8402 doi:10.1002/ehf2.12909 PMID 32810367 ISI:000560208700001 1234665460 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1234665460 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1002.ehf2.12909 |
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