مورد إلكتروني
Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons
| العنوان: | Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons |
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| بيانات النشر: | KTH, Science for Life Laboratory, SciLifeLab KTH, Skolan för datavetenskap och kommunikation (CSC) Stockholm Brain Institute, Karolinska Institute, 171 77 Solna, Sweden;bDepartment of Neuroscience, Karolinska Institute, 171 77 Solna National Academy of Sciences 2017 |
| تفاصيل مُضافة: | Du, K. Wu, Y. -W Lindroos, R. Liu, Y. Rózsa, B. Katona, G. Ding, J. B. Hellgren Kotaleski, Jeanette |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Striatal spiny projection neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex and thalamus. Activation of spatially clustered and temporally synchronized excitatory inputs at the distal dendrites could trigger plateau potentials in SPNs. Such supralinear synaptic integration is crucial for dendritic computation. However, how plateau potentials interact with subsequent excitatory and inhibitory synaptic inputs remains unknown. By combining computational simulation, two-photon imaging, optogenetics, and dual-color uncaging of glutamate and GABA, we demonstrate that plateau potentials can broaden the spatiotemporal window for integrating excitatory inputs and promote spiking. The temporal window of spiking can be delicately controlled by GABAergic inhibition in a cell-type–specific manner. This subtle inhibitory control of plateau potential depends on the location and kinetics of the GABAergic inputs and is achieved by the balance between relief and reestablishment of NMDA receptor Mg2+ block. These findings represent a mechanism for controlling spatiotemporal synaptic integration in SPNs. QC 20180117 |
| مصطلحات الفهرس: | Dendritic computation, Inhibition, Plateau potential, Striatum, Synaptic integration, 4 aminobutyric acid, glutamic acid, magnesium ion, n methyl dextro aspartic acid receptor, adult, animal cell, animal tissue, Article, cell specificity, cell synchronization, dendrite, female, GABAergic system, male, mouse, nerve cell, nerve cell excitability, nonhuman, optogenetics, priority journal, simulation, spike, striatal spiny projection neuron, synaptic transmission, Neurosciences, Neurovetenskaper, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1073.pnas.1704893114 |
| URL: | Proceedings of the National Academy of Sciences of the United States of America, 0027-8424, 2017, 114:36, s. E7612-E7621 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:kth-218816 0000-0002-0550-0739 doi:10.1073/pnas.1704893114 PMID 28827326 ISI:000409182200023 Scopus 2-s2.0-85029221172 1234936259 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1234936259 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1073.pnas.1704893114 |
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