مورد إلكتروني
Streptozotocin-diabetes in the Chinese hamster. Blood glucose and structural changes during the first 24 hours
| العنوان: | Streptozotocin-diabetes in the Chinese hamster. Blood glucose and structural changes during the first 24 hours |
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| بيانات النشر: | Uppsala universitet, Medicinska fakulteten 1972 |
| تفاصيل مُضافة: | Wilander, Erik Boquist, L. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Intraperitoneal administration of 200 mg/kg body weight of streptozotocin to non-diabetic adult Chinese hamsters, evoked a triphasic blood glucose response. There was a hyperglycemic peak after 3 hours and a hypoglycemic phase with a minimum at 6 hours, after which time there was a rather rapid return to hyperglycemia. Light and electron microscopic examinations during the first 24 hours after the injection of streptozotocin showed pyknosis, vacuolization, marked degeneration and necrosis of the β-cells. Degenerative and necrotic changes were also seen in a few α2-cells. The results denote that in the Chinese hamster streptozotocin has an early and direct cytotoxic action on the β-cells and probably also on a few α2-cells. |
| مصطلحات الفهرس: | Chinese Hamster, Streptozotocin, Pancreatic Islets, β-Cell Degeneration, α2-Cell Degeneration, Hyperglycemia, Medical and Health Sciences, Medicin och hälsovetenskap, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1055.s-0028-1094000 |
| URL: | Hormone and Metabolic Research, 0018-5043, 1972, 4:6, s. 426-433 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:uu-180770 doi:10.1055/s-0028-1094000 PMID 4120450 ISI:A1972O420800005 1235066710 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1235066710 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1055.s-0028-1094000 |
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