مورد إلكتروني
Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans
| العنوان: | Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans |
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| بيانات النشر: | Uppsala universitet, Enheten för klinisk näringsforskning Uppsala universitet, Enheten för klinisk näringsforskning Uppsala universitet, Enheten för klinisk näringsforskning 2006 |
| تفاصيل مُضافة: | Nälsén, C Vessby, Bengt Berglund, L Uusitupa, M Hermansen, K Riccardi, G Rivellese, A Storlien, L Erkkilä, A Ylä-Herttuala, S Tapsell, L Basur, Samar |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | (n-3) Fatty acids are unsaturated and are therefore easily subject to oxidization; however, they have several beneficial health effects, which include protection against cardiovascular diseases. The aim of this study was to investigate whether (n-3) fatty acids, with a controlled fat quality in the background diet, affect nonenzymatic and enzymatic lipid peroxidation and antioxidant status in humans. A total of 162 men and women in a multicenter study (The KANWU study) were randomly assigned to a diet containing a high proportion of saturated fatty acids or monounsaturated fatty acids (MUFA) for 3 mo. Within each diet group, there was a second random assignment to supplementation with fish-oil capsules [3.6 g (n-3) fatty acids/d] or placebo. Biomarkers of nonenzymatic and enzymatic lipid peroxidation in vivo were determined by measuring 8-iso-prostaglandin F2α (8-iso-PGF2α) and prostaglandin F2α (PGF2α) concentrations in plasma at baseline and after 3 mo. Antioxidant status was determined by measuring plasma antioxidant capacity with an enhanced chemiluminescence assay. The plasma 8-iso-PGF2α concentration was significantly decreased after 3 mo of supplementation with (n-3) fatty acids (P = 0.015), whereas the PGF2α concentration was not affected. The antioxidant status was not affected by supplementation of (n-3) fatty acids, but was improved by the background diet with a high proportion of MUFA. We conclude that supplementation with (n-3) fatty acids decreases nonenzymatic free radical–catalyzed isoprostane formation, but does not affect cyclooxygenase-mediated prostaglandin formation. |
| مصطلحات الفهرس: | Administration; Oral, Comparative Study, Diet, Dinoprost/*blood, Energy Intake, F2-Isoprostanes/*blood, Fatty Acids/administration & dosage/pharmacology, Fatty Acids; Omega-3/administration & dosage/*pharmacology, Female, Humans, Male, Reference Values, Research Support; Non-U.S. Gov't, Medical and Health Sciences, Medicin och hälsovetenskap, Article in journal, info:eu-repo/semantics/article, text |
| URL: | Journal of Nutrition, 0022-3166, 2006, 136:5, s. 1222-1228 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:uu-94252 PMID 16614408 1235122411 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1235122411 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |