مورد إلكتروني
Sinteza i biomedicinska ispitivanja novih bioizostera stiril-laktona i antitumorskog agensa tiazofurina
| العنوان: | Sinteza i biomedicinska ispitivanja novih bioizostera stiril-laktona i antitumorskog agensa tiazofurina |
|---|---|
| المصدر: | Универзитет у Новом Саду |
| بيانات النشر: | Универзитет у Новом Саду, Природно-математички факултет 2018-09-26 |
| تفاصيل مُضافة: | Popsavin, Mirjana Popsavin, Velimir Kojić, Vesna Popović, Boris Svirčev, Miloš |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | U ovom radu prikazana je sinteza 11 tiazolnih izostera goniofufurona (1-11), 4 konformaciono kruta analoga goniofufurona (12-15) i jednog butadiolnog derivata tiazofurina (16). Takođe, izvršeno je ispitivanje i poređenje bioloških aktivnosti sintetisanih analoga sa sa aktivnošću i selektivnošću kako GF i TF tako i doksorubicina, jedinjenja širokog spektra dejstva (DOX). Hiralni prekursor novosintetisanih jedinjenja 1-15 bila je D-glukoza, a jedinjenja 16 D-arabinoza. A multistep synthesis of 11 novel thiazole isosteres of goniofufurone (1-11), 4 novel conformationally constrained isosteres of goniofufurone (12-15), as well as one butanediole derivative of tiazofurin (16) has been achieved. In vitro cytotoxicity of newly synthetized derivatives has been evaluated and compared with the cytotoxicities of goniofufurone, tiazofurin and doxorubicin. |
| مصطلحات الفهرس: | (+)-Goniofufuron, tiazofurin, citotoksični laktoni, C-nukleozidi, D-glukoza, Darabinoza., (+)-Goniofufurone, cytotoxic lactones, C-nucleosides, D-glucose, Darabinose, doctoralThesis |
| URL: | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS |
| الإتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by-nc/4.0 BY-NC openAccess |
| أرقام أخرى: | RSPST oai:nardus.mpn.gov.rs:123456789/10366 https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija153190153401444.pdf?controlNumber=(BISIS)107610&fileName=153190153401444.pdf&id=11729&source=NaRDuS&language=sr https://www.cris.uns.ac.rs/record.jsf?recordId=107610&source=NaRDuS&language=sr https://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije15319015464675.pdf?controlNumber=(BISIS)107610&fileName=15319015464675.pdf&id=11730&source=NaRDuS&language=sr https://hdl.handle.net/21.15107/rcub_nardus_10366 1242115287 |
| المصدر المساهم: | UIVERSITY OF BELGRADE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1242115287 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |