مورد إلكتروني
Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects
| العنوان: | Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects |
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| المصدر: | Journal of Bioactive and Compatible Polymers |
| بيانات النشر: | Sage Publications Ltd, London 2020 |
| تفاصيل مُضافة: | Ponjavić, Marijana Nikolić, Marija Stevanović, Sanja Nikodinović-Runić, Jasmina Jeremić, Sanja Pavić, Aleksandar Đonlagić, Jasna |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Star-shaped polymers of biodegradable aliphatic polyester, poly(epsilon-caprolactone), PCL, with different number of arms (three, four, and six) were synthesized by ring-opening polymerization initiated by multifunctional alcohols used as cores. As potential biomaterials, synthesized star-shaped poly(epsilon-caprolactone)s,sPCL, were thoroughly characterized in terms of their degradation under different pH conditions and in respect to their cytotoxicity. The in vitro degradation was performed in phosphate buffer (pH 7.4) and hydrochloric acid solution (pH 1.0) over 5 weeks. Degradation ofsPCL films was followed by the weight loss measurements, GPC, FTIR, and AFM analysis. While the most of the samples were stable against the abiotic hydrolysis at pH 7.4 after 5 weeks of degradation, degradation was significantly accelerated in the acidic medium. Degradation rate of polymer films was affected by the polymer architecture and molecular weight. The molecular weight profiles during the degradation revealed random chain scission of the ester bonds indicating bulk degradation mechanism of hydrolysis at pH 7.4, while acidic hydrolysis proceeded through the bulk degradation associated with surface erosion, confirmed by AFM. The in vitro toxicity tests, cytotoxicity applying normal human fibroblasts (MRC5) and embryotoxicity assessment (using zebra fish model,Danio rerio), suggested those polymeric materials as suitable for biomedical application. |
| مصطلحات الفهرس: | Star-shaped PCLs, hydrolysis at different pH, cytotoxycity, embryotoxycity, article |
| URL: | info:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS info:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS |
| الإتاحة: | Open access content. Open access content ARR restrictedAccess |
| ملاحظة: | Journal of Bioactive and Compatible Polymers |
| أرقام أخرى: | RSPST oai:TechnoRep.tmf.bg.ac.rs:123456789/4394 0883-9115 10.1177/0883911520951826 conv_6197 2-s2.0-85090200992 000565911800001 1242560657 |
| المصدر المساهم: | UIVERSITY OF BELGRADE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1242560657 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |