مورد إلكتروني
Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors
| العنوان: | Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors |
|---|---|
| بيانات النشر: | Multidisciplinary Digital Publishing Institute 2019-04-16 |
| تفاصيل مُضافة: | Consejo Superior de Investigaciones Científicas (España) Hungarian Academy of Sciences University of Szeged Ministry of Human Capacities (Hungary) Mosolygó, Tímea Kincses, Annamária Csonka, Andrea Tönki, Ádám Szabó Witek, Karolina Sanmartín, Carmen Marć, Małgorzata Anna Handzlik, Jadwiga Kieć-Kononowicz, Katarzyna Domínguez-Álvarez, Enrique Spengler, Gabriella |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated. The effects of eleven selenocompounds on bacterial growth were evaluated in Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Enterococcus faecalis, Escherichia coli, and Chlamydia trachomatis D. The combination effect of compounds with antibiotics was examined by the minimum inhibitory concentration reduction assay. Their efflux pump (EP) inhibitory properties were assessed using real-time fluorimetry. Relative expressions of EP and quorum-sensing genes were studied by quantitative PCR. Results showed that a methylketone selenoester had remarkable antibacterial activity against Gram-positive bacteria and potentiated the activity of oxacillin in MRSA. Most of the selenocompounds showed significant anti-chlamydial effects. The selenoanhydride and the diselenodiester were active inhibitors of the AcrAB-TolC system. Based on these results it can be concluded that this group of selenocompounds can be attractive potential antibacterials and EP inhibitors. The discovery of new derivatives with a significant antibacterial activity as novel selenocompounds, is of high impact in the fight against resistant pathogens. |
| مصطلحات الفهرس: | Selenocompounds, Selenoesters, AcrAB-TolC efflux pump, Chlamydia trachomatis D, Escherichia coli K-12 AG100, Staphylococcus aureus, artículo |
| URL: | Publisher's version Sí |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-sa/4.0 openAccess |
| أرقام أخرى: | CTK oai:digital.csic.es:10261/180727 Molecules 24(8): 1487 (2019) 1420-3049 10.3390/molecules24081487 31014009 1257717658 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1257717658 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |