مورد إلكتروني
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD : a systematic review and meta-analysis
| العنوان: | Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD : a systematic review and meta-analysis |
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| بيانات النشر: | Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, The Netherlands Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, The Netherlands Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, The Netherlands Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK UCM Digestive Diseases, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Sevilla, Spain; Center for Infectious Diseases, West China Hospital of Sichuan University; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK UCM Digestive Diseases, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Sevilla, Spain Internal Medicine Research Unit, Pfizer Inc, Cambridge, MA, USA Internal Medicine Research Unit, Pfizer Inc, Cambridge, MA, USA Liver Research Group, Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, The Netherlands Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK 2021 |
| تفاصيل مُضافة: | Selvaraj, Emmanuel Anandraj Mózes, Ferenc Emil Ajmer Jayaswal, Arjun Narayan Zafarmand, Mohammad Hadi Vali, Yasaman Lee, Jenny A. Levick, Christina Kim Joseph Young, Liam Arnold Palaniyappan, Naaventhan Liu, Chang-Hai Aithal, Guruprasad Padur Romero-Gómez, Manuel Brosnan, M. Julia Tuthill, Theresa A. Anstee, Quentin M. Neubauer, Stefan Harrison, Stephen A. Bossuyt, Patrick M. Pavlides, Michael |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND AND AIMS: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), two-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) are proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH). METHODS: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests against histology as the reference standard, in adult patients with NAFLD. Two authors independently screened and assessed methodological quality of studies and extracted data. Summary estimates of sensitivity, specificity and area under the curve (sAUC) were calculated for fibrosis stages and NASH, using a random effects bivariate logit-normal model. RESULTS: We included 82 studies (14,609 patients). Meta-analysis for diagnosing fibrosis stages was possible in 53 VCTE, 11 MRE, 12 pSWE and four 2DSWE studies, and for diagnosing NASH in four MRE studies. sAUC for diagnosis of significant fibrosis were: 0.83 for VCTE, 0.91 for MRE, 0.86 for pSWE and 0.75 for 2DSWE. sAUC for diagnosis of advanced fibrosis were: 0.85 for VCTE, 0.92 for MRE, 0.89 for pSWE and 0.72 for 2DSWE. sAUC for diagnosis of cirrhosis were: 0.89 for VCTE, 0.90 for MRE, 0.90 for pSWE and 0.88 for 2DSWE. MRE had sAUC of 0.83 for diagnosis of NASH. Three (4%) studies reported intention-to-diagnose analyses and 15 (18%) studies reported diagnostic accuracy against pre-specified cut-offs. CONCLUSIONS: When elastography index tests are acquired successfully, they have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these index tests cannot be assessed fully as intention-to-diagnose analyses and validation of pre-specified thresholds are lacking. LAY SUMMARY: Non-invasive tests that meas ReviewFunding agencies:Innovative Medicines Initiative 2 Joint Undertaking 777377Europen Federation of Pharmaceutical Industries and Associations (efpia.eu) |
| مصطلحات الفهرس: | Biomarkers, Diffusion weighted imaging, Iron-corrected T1, Liver fibrosis, Magnetic resonance elastography, Magnetic resonance imaging, NASH-MRI, Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Shear wave elastography, Transient elastography, deMILI, fibro-MRI, Gastroenterology and Hepatology, Gastroenterologi, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1016.j.jhep.2021.04.044 |
| URL: | Journal of Hepatology, 0168-8278, 2021, 75:4, s. 770-785 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:oru-91805 doi:10.1016/j.jhep.2021.04.044 PMID 33991635 ISI:000701809900006 Scopus 2-s2.0-85108940286 1261883443 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1261883443 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1016.j.jhep.2021.04.044 |
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