مورد إلكتروني
Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response
العنوان: | Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response |
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المصدر: | Pharmacology |
بيانات النشر: | S. Karger AG 2008 |
تفاصيل مُضافة: | Mellor, Howard R. Callaghan, Richard |
نوع الوثيقة: | Electronic Resource |
مستخلص: | Inherent and acquired resistance pathways account for the high rate of failure in cancer chemotherapy. The mechanisms or pathways mediating resistance may be classified as pharmacokinetic (i.e. alter intratumour drug exposue) or pharmacodynamic (i.e. failure to elicit cytotoxicity). More often than not, the resistant phenotype is characterised by alterations in multiple pathways. Consequently, the pathways may act synergistically or generate a broad spectrum of resistance to anticancer drugs. There has been a great deal of systematic characterisation of drug resistance in vitro. However, translating this greater understanding into clinical efficacy has rarely been achieved. This review explores the phenomenon of drug resistance in cancer and highlights the gap between in vitro and in vivo observations. This gap presents a major obstacle in overcoming drug resistance and restoring sensitivity to chemotherapy. |
مصطلحات الفهرس: | Keywords: anthracycline; bleomycin; carboplatin; carmustine; cisplatin; cyclophosphamide; daunorubicin; dj 927; docetaxel; doxorubicin; elacridar; epirubicin; fluorouracil; gemcitabine; hycamptin; idarubicin; ifosfamide; irinotecan; lomeguatrib; methotrexate; mitom Anticancer drugs; Cancer chemotherapy; Drug resistance; Multidrug resistance; Pharmacodynamic resistance; Pharmacokinetic resistance, Journal article |
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الإتاحة: | Open access content. Open access content |
أرقام أخرى: | AUANP oai:openresearch-repository.anu.edu.au:1885/71240 0031-7012 1291798711 |
المصدر المساهم: | AUSTRALIAN NAT UNIV - PRINT REPOSITORY From OAIster®, provided by the OCLC Cooperative. |
رقم الأكسشن: | edsoai.on1291798711 |
قاعدة البيانات: | OAIster |
الوصف غير متاح. |