مورد إلكتروني
ZSWIM1: A novel biomarker in T helper cell differentiation.
| العنوان: | ZSWIM1: A novel biomarker in T helper cell differentiation. |
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| بيانات النشر: | Elsevier Netherlands 2014-06-25 |
| تفاصيل مُضافة: | Hogarth P.M. Ko K.K. Powell M.S. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The effector memory CD4+ Th17 cells play critical roles in bacterial immunity and pathological inflammation in autoimmune conditions. ZSWIM1 is a gene encoding a protein of unknown function in leukocytes-but containing a zinc finger SWIM motif. In peripheral blood mononuclear cells, the expression of ZSWIM1 is highest in lymphocytes, and in particular shows greatest abundance in naive CD4+ T cells. Upon polarisation of naive CD4+ T cells, ZSWIM1 expression is retained in Th17 cells but is selectively down regulated in Th1 cells. Similarly in in vitro expanded effector memory CD4+ T cells, ZSWIM1 was more abundant in Th17 cells compared to Th1 or Th17 polyfunctional (Th17pf) cells, which produce IL-17A and IFNgamma. Although stimulation of cytokine production by PMA and ionomycin reduced ZSWIM1 expression, the relative differences in abundance between the cell types were maintained. The activation sensitive nature of ZSWIM1 expression suggests that it may play a novel role in the development or function of T helper cells. © 2014 Elsevier B.V. |
| مصطلحات الفهرس: | gamma interferon/ec [Endogenous Compound], polymerase chain reaction, priority journal, protein motif, Th1 cell, Th17 cell, interleukin 17/ec [Endogenous Compound], ZSWIM1 gene, zinc finger protein/ec [Endogenous Compound], ionomycin, article, CD4+ T lymphocyte, cell differentiation, cell isolation, controlled study, cytokine production, down regulation, gene, gene expression, helper cell, human, human cell, in vitro study, lymphocyte culture, peripheral blood mononuclear cell, polarization, Article |
| URL: | Immunology Letters Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2015 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/41989 Immunology Letters. 160 (2) (pp 133-138), 2014. Date of Publication: August 2014. 0165-2478 https://repository.monashhealth.org/monashhealthjspui/handle/1/41989 24508175 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24508175] 53028917 (Ko, Powell, Hogarth) Centre for Biomedical Research, Burnet Institute, Melbourne 3004, VIC, Australia (Ko, Powell, Hogarth) Department of Pathology, University of Melbourne, Melbourne 3084, VIC, Australia (Powell) School of Public Health and Preventive Medicine, Monash University, Clayton 3168, VIC, Australia (Hogarth) Department of Immunology, Monash University, Melbourne 3004, VIC, Australia (Powell) Monash Centre for Health Research and Implementation Schoolof Public Health, Preventive Medicine, Monash University-in partnership with Monash Health Locked Bag 29, Clayton 3168, VIC, Australia Ko K.K.; kko@burnet.edu.au Hogarth P.M.; pmhogarth@burnet.edu.au Powell M.S.; maree.powell@monash.edu 1305113161 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1305113161 |
| قاعدة البيانات: | OAIster |
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