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Catheter Ablation Versus Medication in Atrial Fibrillation and Systolic Dysfunction: Late Outcomes of CAMERA-MRI Study.

التفاصيل البيبلوغرافية
العنوان: Catheter Ablation Versus Medication in Atrial Fibrillation and Systolic Dysfunction: Late Outcomes of CAMERA-MRI Study.
بيانات النشر: Elsevier Inc. United States 2021-04-01
تفاصيل مُضافة: Taylor A.J.
Kalman J.M.
Kistler P.M.
Sugumar H.
Prabhu S.
Costello B.
Chieng D.
Azzopardi S.
Voskoboinik A.
Parameswaran R.
Wong G.R.
Anderson R.
Al-Kaisey A.M.
Ling L.-H.
Kotschet E.
نوع الوثيقة: Electronic Resource
مستخلص: Objectives: This study sought to determine the long-term outcomes of restoring sinus rhythm with catheter ablation (CA). Background(s): The CAMERA-MRI (Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Heart Failure-An MRI-Guided Multicenter Randomized Controlled Trial) study demonstrated that restoration of sinus rhythm with CA significantly improved left ventricular ejection fraction (LVEF) compared with medical rate control (MRC) at 6 months in persistent atrial fibrillation and otherwise unexplained systolic heart failure. However, the long-term outcomes have not been reported. Method(s): Patients enrolled in the CAMERA-MRI study were followed for 4 years with echocardiogram and cardiac magnetic resonance. CA involved pulmonary vein isolation and posterior left atrial wall isolation in 94%. Patients crossed over to CA after 6-month study duration. Arrhythmia burden was determined with implanted cardiac monitors or cardiac devices. Result(s): Sixty-six patients (age 62 +/- 10 years, atrial fibrillation duration of 22 +/- 16 months, and LVEF 33 +/- 9%) were randomized 1:1 to CA versus MRC. Eighteen of 33 patients crossed over from MRC group to CA group. At 4.0 +/- 0.9 years, atrial fibrillation recurred in 27 patients (57%) in the CA group with a mean burden of 10.6 +/- 21.2% after 1.4 +/- 0.6 procedures. There was an absolute increase in LVEF with CA of 16.4 +/- 13.3% compared with 8.6 +/- 7.6% in MRC (p = 0.001). In the CA group, the absence of ventricular late gadolinium enhancement was associated with a greater improvement in absolute LVEF (19 +/- 13% vs. 10 +/- 11% in the late gadolinium enhancement-positive group; p = 0.04) and LVEF normalization in 19 patients (58%) versus 4 patients (18%) in the late gadolinium enhancement-positive group (p = 0.008) at 4.0 +/- 0.9 years follow-up. Conclusion(s): CA is superior to MRC in improving LVEF in the long term in patients with atrial fibrillation and systolic heart failure. The greatest recov
مصطلحات الفهرس: multicenter study, open study, outcome assessment, persistent atrial fibrillation, priority journal, prospective study, pulmonary vein isolation, radiofrequency ablation, randomized controlled trial, recurrent disease, sinus rhythm, six minute walk test, systolic dysfunction/dt [Drug Therapy], systolic heart failure, transthoracic echocardiography, angiotensin receptor antagonist/ct [Clinical Trial], angiotensin receptor antagonist/pv [Special Situation for Pharmacovigilance], antiarrhythmic agent/ct [Clinical Trial], antiarrhythmic agent/dt [Drug Therapy], antiarrhythmic agent/pv [Special Situation for Pharmacovigilance], anticoagulant agent/pv [Special Situation for Pharmacovigilance], beta adrenergic receptor blocking agent/ct [Clinical Trial], beta adrenergic receptor blocking agent/pv [Special Situation for Pharmacovigilance], cardiovascular agent/ct [Clinical Trial], cardiovascular agent/dt [Drug Therapy], dipeptidyl carboxypeptidase inhibitor/ct [Clinical Trial], dipeptidyl carboxypeptidase inhibitor/pv [Special Situation for Pharmacovigilance], gadolinium pentetate meglumine, sacubitril, spironolactone/ct [Clinical Trial], spironolactone/pv [Special Situation for Pharmacovigilance], cardiac equipment, dual chamber pacemaker, Holter monitor, implantable cardiac monitor, implantable cardioverter defibrillator, nuclear magnetic resonance scanner, radiofrequency ablation device, CONFIRM, Reveal LINQ, Signa HD, adult, aged, article, atrial fibrillation/dt [Drug Therapy], atrial fibrillation/th [Therapy], cardiac resynchronization therapy, cardiovascular magnetic resonance, catheter ablation, CHA2DS2-VASc score, controlled study, crossover procedure, disease duration, echocardiography, electrocardiogram, female, follow up, heart atrioventricular node, heart left atrium, heart left ventricle ejection fraction, heart left ventricle enddiastolic volume, heart left ventricle endsystolic diameter, Holter monitoring, human, major clinical study, male, middle aged, Article
URL: https://repository.monashhealth.org/monashhealthjspui/handle/1/26814
JACC: Clinical Electrophysiology
LibKey Link
الإتاحة: Open access content. Open access content
Copyright 2021 Elsevier B.V., All rights reserved.
أرقام أخرى: AUSHL oai:repository.monashhealth.org:1/26814
JACC: Clinical Electrophysiology. 6 (13) (pp 1721-1731), 2020. Date of Publication: 14 Dec 2020.
2405-500X
https://repository.monashhealth.org/monashhealthjspui/handle/1/26814
33334453 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33334453]
2008588412
(Sugumar, Prabhu, Costello, Chieng, Azzopardi, Voskoboinik, Taylor, Kistler) Department of Cardiology, The Baker Heart Research Institute, Melbourne, Australia (Sugumar, Prabhu, Costello, Chieng, Azzopardi, Voskoboinik, Parameswaran, Wong, Al-Kaisey, Ling, Taylor, Kistler) Department of Cardiology, The Alfred Hospital, Melbourne, Australia (Sugumar, Chieng, Voskoboinik, Parameswaran, Wong, Anderson, Al-Kaisey, Kalman) Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia (Sugumar, Prabhu, Chieng, Voskoboinik, Parameswaran, Wong, Anderson, Al-Kaisey, Ling, Kalman, Kistler) Department of Cardiology, University of Melbourne, Melbourne, Australia (Kotschet) Department of Cardiology, Monash Health, Melbourne, Australia
Kistler P.M.; peter.kistler@baker.edu.au
(Sugumar, Prabhu, Costello, Chieng, Azzopardi, Voskoboinik, Taylor, Kistler) Department of Cardiology, The Baker Heart Research Institute, Melbourne, Australia
(Sugumar, Prabhu, Costello, Chieng, Azzopardi, Voskoboinik, Parameswaran, Wong, Al-Kaisey, Ling, Taylor, Kistler) Department of Cardiology, The Alfred Hospital, Melbourne, Australia
(Sugumar, Chieng, Voskoboinik, Parameswaran, Wong, Anderson, Al-Kaisey, Kalman) Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
(Sugumar, Prabhu, Chieng, Voskoboinik, Parameswaran, Wong, Anderson, Al-Kaisey, Ling, Kalman, Kistler) Department of Cardiology, University of Melbourne, Melbourne, Australia
(Kotschet) Department of Cardiology, Monash Health, Melbourne, Australia
1305115943
المصدر المساهم: MONASH HEALTH LIBRS
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