مورد إلكتروني
أعرض في EDS

A randomised controlled trial of paracetamol and ibuprofen with or without codeine or oxycodone as initial analgesia for adults with moderate pain from limb injury.

التفاصيل البيبلوغرافية
العنوان: A randomised controlled trial of paracetamol and ibuprofen with or without codeine or oxycodone as initial analgesia for adults with moderate pain from limb injury.
بيانات النشر: Blackwell Publishing (E-mail: info@asia.blackpublishing.com.au) Australia 2016-12-17
تفاصيل مُضافة: Egerton-Warburton D.
Meyer A.
Parkinson J.
Meek R.
Graudins A.
نوع الوثيقة: Electronic Resource
مستخلص: Objective: Compare pain relief from non-opioid, codeine and oxycodone analgesic regimens in adults with moderate pain from limb injury. Method(s): Double-blind, randomised, controlled, non-inferiority trial. Three regimens of six tablets, each included 2 x 500 mg paracetamol and 2 x 200 mg ibuprofen with 2 x 100 mg thiamine (non-opioid), 2 x 30 mg codeine (codeine) or 2 x 5 mg oxycodone tablets (oxycodone). Primary Outcome: difference in mean visual analogue scale (VAS) change between groups at 30 min, with a limit of inferiority of 13. Secondary outcomes included mean change in VAS rating from baseline to 30 min for each group, patient satisfaction, need for additional analgesia and adverse events. Pain ratings taken at 60 and 90 min for patients still in ED are described. Result(s): Of 182 patients randomised, non-opioid, codeine and oxycodone numbers were 61, 62 and 59. Differences (95% CI) between groups at 30 min were as follows: non-opioid versus codeine -2.6 (-8.8 to 3.6); non-opioid versus oxycodone -2.7 (-9.3 to 3.9); codeine versus oxycodone 0.1 (-6.6 to 6.4). Mean VAS reductions for non-opioid, codeine and oxycodone were -13.5, -16.1 and -16.2 mm, respectively. Satisfaction with analgesia was reported by 77.6% (64.7-87.5), 81.0% (67.2-89.0) and 73.6% (59.7-84.7) and adverse events by 3.3% (0.4-11.3), 1.6% (0.4-8.7) and 16.9% (8.4-29.0), respectively. Mean VAS reductions at 60 and 90 min were as follows: -23.2 and -18.7 mm for non-opioid; -30.7 and -33.3 mm for codeine; and -26.1 and -31.7 mm for oxycodone. Conclusion(s): At 30 min, analgesic effects of non-opioid, codeine and oxycodone groups were non-inferior.Copyright © 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine
مصطلحات الفهرس: limb pain/dt [Drug Therapy], major clinical study, male, nausea/si [Side Effect], patient satisfaction, priority journal, randomized controlled trial, retrospective study, treatment outcome, unspecified side effect/si [Side Effect], visual analog scale, codeine phosphate/ae [Adverse Drug Reaction], codeine phosphate/ct [Clinical Trial], codeine phosphate/dt [Drug Therapy], ibuprofen/ct [Clinical Trial], ibuprofen/dt [Drug Therapy], oxycodone/ae [Adverse Drug Reaction], oxycodone/ct [Clinical Trial], oxycodone/dt [Drug Therapy], paracetamol/ct [Clinical Trial], paracetamol/dt [Drug Therapy], thiamine/ae [Adverse Drug Reaction], thiamine/ct [Clinical Trial], thiamine/dt [Drug Therapy], pilot study, adult, aged, analgesia, article, cohort analysis, controlled study, dizziness/si [Side Effect], double blind procedure, drowsiness/si [Side Effect], drug efficacy, drug safety, female, heartburn/si [Side Effect], human, limb injury, limb pain/co [Complication], Article
URL: https://repository.monashhealth.org/monashhealthjspui/handle/1/39826
EMA - Emergency Medicine Australasia
LibKey Link
الإتاحة: Open access content. Open access content
Copyright 2017 Elsevier B.V., All rights reserved.
أرقام أخرى: AUSHL oai:repository.monashhealth.org:1/39826
EMA - Emergency Medicine Australasia. 28 (6) (pp 666-672), 2016. Date of Publication: 01 Dec 2016.
1742-6731
https://repository.monashhealth.org/monashhealthjspui/handle/1/39826
27599896 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27599896]
612975003
(Graudins) Monash Health Emergency Medicine Research Unit, Dandenong Hospital, Melbourne, VIC, Australia (Graudins, Meek) Monash Emergency, Dandenong Hospital, Melbourne, VIC, Australia (Egerton-Warburton) Monash Emergency, Monash Medical Center, Melbourne, VIC, Australia (Meyer) Monash Emergency, Casey Hospital, Melbourne, VIC, Australia (Parkinson) Pharmacy Department, Monash Medical Center, Melbourne, VIC, Australia (Graudins, Meek, Parkinson, Egerton-Warburton, Meyer) School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia
Graudins A.; andis.graudins@monashhealth.org
1305118882
المصدر المساهم: MONASH HEALTH LIBRS
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رقم الأكسشن: edsoai.on1305118882
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