مورد إلكتروني
Albumin and hyaluronic acid-coated superparamagnetic iron oxide nanoparticles loaded with paclitaxel for biomedical applications
| العنوان: | Albumin and hyaluronic acid-coated superparamagnetic iron oxide nanoparticles loaded with paclitaxel for biomedical applications |
|---|---|
| بيانات النشر: | MDPI AG 2017 |
| تفاصيل مُضافة: | Vismara, E Bongio, C Coletti, A Edelman, R Serafini, A Mauri, M Simonutti, R Bertini, S Urso, E Assaraf, Y Livney, Y Vismara, E Bongio, C Coletti, A Edelman, R Serafini, A Bertini, S Urso, E Assaraf, Y Livney, Y. MAURI, MICHELE SIMONUTTI, ROBERTO |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe3O4·DA-BSA/HA in water. Fe3O4·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe3O4·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system. |
| مصطلحات الفهرس: | Bovine serum albumin (BSA), Fe3O4·DA-BSA/HA, Hyaluronic acid (HA), Magnetic resonance imaging (MRI), Paclitaxel (PTX), Super paramagnetic iron oxide nanoparticles (SPION), Medicine (all), Organic Chemistry, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/28640222 info:eu-repo/semantics/altIdentifier/wos/WOS:000406621300004 volume:22 issue:7 journal:MOLECULES |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| أرقام أخرى: | ITBAO oai:boa.unimib.it:10281/161393 10.3390/molecules22071030 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85021296265 1308921833 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1308921833 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |