مورد إلكتروني
The Efficacy of Anti-Arrhythmic Drugs in Children With Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia:a Retrospective Multi-Center Study
| العنوان: | The Efficacy of Anti-Arrhythmic Drugs in Children With Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia:a Retrospective Multi-Center Study |
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| المؤلفون: | Bertels, Robin A., Kammeraad, Janneke A.E., Zeelenberg, Anna M., Filippini, Luc H., Knobbe, Ingmar, Kuipers, Irene M., Blom, Nico A. |
| المصدر: | Bertels , R A , Kammeraad , J A E , Zeelenberg , A M , Filippini , L H , Knobbe , I , Kuipers , I M & Blom , N A 2021 , ' The Efficacy of Anti-Arrhythmic Drugs in Children With Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia : a Retrospective Multi-Center Study ' , Pediatric Cardiology , vol. 42 , no. 4 , pp. 883-890 . |
| بيانات النشر: | 2021-04 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The aim of the study is to compare the efficacy of flecainide, beta-blockers, sotalol, and verapamil in children with frequent PVCs, with or without asymptomatic VT. Frequent premature ventricular complexes (PVCs) and asymptomatic ventricular tachycardia (VT) in children with structurally normal hearts require anti-arrhythmic drug (AAD) therapy depending on the severity of symptoms or ventricular dysfunction; however, data on efficacy in children are scarce. Both symptomatic and asymptomatic children (≥ 1 year and < 18 years of age) with a PVC burden of 5% or more, with or without asymptomatic runs of VT, who had consecutive Holter recordings, were included in this retrospective multi-center study. The groups of patients receiving AAD therapy were compared to an untreated control group. A medication episode was defined as a timeframe in which the highest dosage at a fixed level of a single drug was used in a patient. A total of 35 children and 46 medication episodes were included, with an overall change in PVC burden on Holter of -4.4 percentage points, compared to -4.2 in the control group of 14 patients. The mean reduction in PVC burden was only significant in patients receiving flecainide (− 13.8 percentage points; N = 10; p = 0.032), compared to the control group and other groups receiving beta-blockers (− 1.7 percentage points; N = 18), sotalol (+ 1.0 percentage points; N = 7), or verapamil (− 3.9 percentage points; N = 11). The efficacy of anti-arrhythmic drug therapy on frequent PVCs or asymptomatic VTs in children is very limited. Only flecainide appears to be effective in lowering the PVC burden. |
| مصطلحات الفهرس: | article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | QGQ oai:pure.eur.nl:publications/6e67f349-8ef3-4da2-ba67-54c3f5ab5967 https://pure.eur.nl/en/publications/6e67f349-8ef3-4da2-ba67-54c3f5ab5967 https://doi.org/10.1007/s00246-021-02556-7 https://pure.eur.nl/ws/files/53645957/Bertels2021_Article_TheEfficacyOfAnti_ArrhythmicDr.pdf 1313641459 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1313641459 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |