مورد إلكتروني
Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies
| العنوان: | Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies |
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| المؤلفون: | Bodelon, C, Ambatipudi, S, Dugue, P-A, Johansson, A, Sampson, JN, Hicks, B, Karlins, E, Hutchinson, A, Cuenin, C, Chajes, V, Southey, MC, Romieu, I, Giles, GG, English, D, Polidoro, S, Assumma, M, Baglietto, L, Vineis, P, Severi, G, Herceg, Z, Flanagan, JM, Milne, RL, Garcia-Closas, M |
| بيانات النشر: | BMC 2019-05-17 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: Environmental and genetic factors play an important role in the etiology of breast cancer. Several small blood-based DNA methylation studies have reported risk associations with methylation at individual CpGs and average methylation levels; however, these findings require validation in larger prospective cohort studies. To investigate the role of blood DNA methylation on breast cancer risk, we conducted a meta-analysis of four prospective cohort studies, including a total of 1663 incident cases and 1885 controls, the largest study of blood DNA methylation and breast cancer risk to date. METHODS: We assessed associations with methylation at 365,145 CpGs present in the HumanMethylation450 (HM450K) Beadchip, after excluding CpGs that did not pass quality controls in all studies. Each of the four cohorts estimated odds ratios (ORs) and 95% confidence intervals (CI) for the association between each individual CpG and breast cancer risk. In addition, each study assessed the association between average methylation measures and breast cancer risk, adjusted and unadjusted for cell-type composition. Study-specific ORs were combined using fixed-effect meta-analysis with inverse variance weights. Stratified analyses were conducted by age at diagnosis (< 50, ≥ 50), estrogen receptor (ER) status (+/-), and time since blood collection (< 5, 5-10, > 10 years). The false discovery rate (q value) was used to account for multiple testing. RESULTS: The average age at blood draw ranged from 52.2 to 62.2 years across the four cohorts. Median follow-up time ranged from 6.6 to 8.4 years. The methylation measured at individual CpGs was not associated with breast cancer risk (q value > 0.59). In addition, higher average methylation level was not associated with risk of breast cancer (OR = 0.94, 95% CI = 0.85, 1.05; P = 0.26; P for study heterogeneity = 0.86). We found no evidence of modification of this association by age at diagnosis (P = 0.17), ER status (P = 0.88), time since |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الإتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/251167 Bodelon, C., Ambatipudi, S., Dugue, P. -A., Johansson, A., Sampson, J. N., Hicks, B., Karlins, E., Hutchinson, A., Cuenin, C., Chajes, V., Southey, M. C., Romieu, I., Giles, G. G., English, D., Polidoro, S., Assumma, M., Baglietto, L., Vineis, P., Severi, G. ,... Garcia-Closas, M. (2019). Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies. BREAST CANCER RESEARCH, 21 (1), https://doi.org/10.1186/s13058-019-1145-9. 10.1186/s13058-019-1145-9 1465-542X 1465-5411 1315661547 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315661547 |
| قاعدة البيانات: | OAIster |
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