مورد إلكتروني
A polymorphism in human CD1A is associated with susceptibility to tuberculosis
| العنوان: | A polymorphism in human CD1A is associated with susceptibility to tuberculosis |
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| المؤلفون: | Seshadri, C, Thuong, NTT, Yen, NTB, Bang, ND, Chau, TTH, Thwaites, GE, Dunstan, SJ, Hawn, TR |
| بيانات النشر: | NATURE PUBLISHING GROUP 2014-04-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95% confidence interval: 1.24-2.57; P=0.001). These data strengthen the hypothesis that CD1A-mediated lipid antigen presentation is important for controlling tuberculosis in humans. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/268872 Seshadri, C., Thuong, N. T. T., Yen, N. T. B., Bang, N. D., Chau, T. T. H., Thwaites, G. E., Dunstan, S. J. & Hawn, T. R. (2014). A polymorphism in human CD1A is associated with susceptibility to tuberculosis. GENES AND IMMUNITY, 15 (3), pp.195-198. https://doi.org/10.1038/gene.2014.5. 10.1038/gene.2014.5 1476-5470 1466-4879 1315692945 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315692945 |
| قاعدة البيانات: | OAIster |
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