مورد إلكتروني
Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
| العنوان: | Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population |
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| المؤلفون: | Lee, IR, Molton, JS, Wyres, KL, Gorrie, C, Wong, J, Hoh, CH, Teo, J, Kalimuddin, S, Lye, DC, Archuleta, S, Holt, KE, Gan, Y-H |
| بيانات النشر: | NATURE PORTFOLIO 2016-07-13 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Hypervirulent Klebsiella pneumoniae is an emerging cause of community-acquired pyogenic liver abscess. First described in Asia, it is now increasingly recognized in Western countries, commonly afflicting those with Asian descent. This raises the question of genetic predisposition versus geospecific strain acquisition. We leveraged on the Antibiotics for Klebsiella Liver Abscess Syndrome Study (A-KLASS) clinical trial ongoing in ethnically diverse Singapore, to prospectively examine the profiles of 70 patients together with their isolates' genotypic and phenotypic characteristics. The majority of isolates belonged to capsule type K1, a genetically homogenous group corresponding to sequence-type 23. The remaining K2, K5, K16, K28, K57 and K63 isolates as well as two novel cps isolates were genetically heterogeneous. K1 isolates carried higher frequencies of virulence-associated genes including rmpA (regulator of mucoid phenotype A), kfu (Klebsiella ferric uptake transporter), iuc (aerobactin), iro (salmochelin) and irp (yersiniabactin) than non-K1 isolates. The Chinese in our patient cohort, mostly non-diabetic, had higher prevalence of K1 infection than the predominantly diabetic non-Chinese (Malays, Indian and Caucasian). This differential susceptibility to different capsule types among the various ethnic groups suggests patterns of transmission (e.g. environmental source, familial transmission) and/or genetic predisposition unique to each race despite being in the same geographical location. |
| مصطلحات الفهرس: | Journal Article |
| URL: | NHMRC/1061409 NHMRC/1043822 |
| الإتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/260038 Lee, I. R., Molton, J. S., Wyres, K. L., Gorrie, C., Wong, J., Hoh, C. H., Teo, J., Kalimuddin, S., Lye, D. C., Archuleta, S., Holt, K. E. & Gan, Y. -H. (2016). Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep29316. 10.1038/srep29316 2045-2322 2045-2322 1315694368 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315694368 |
| قاعدة البيانات: | OAIster |
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