مورد إلكتروني
Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low-intensity chemotherapy in acute myeloid leukaemia
| العنوان: | Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low-intensity chemotherapy in acute myeloid leukaemia |
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| المؤلفون: | Tiong, IS, Dillon, R, Ivey, A, Teh, T-C, Nguyen, P, Cummings, N, Taussig, DC, Latif, A-L, Potter, NE, Runglall, M, Russell, NH, Raj, K, Schwarer, AP, Fong, CY, Grigg, AP, Wei, AH |
| بيانات النشر: | WILEY 2020-05-26 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Based on promising results in older adults with acute myeloid leukaemia (AML), we treated patients with NPM1mut measurable residual disease (MRD) using off-label venetoclax in combination with low-dose cytarabine or azacitidine. Twelve consecutive patients were retrospectively identified, including five with molecular persistence and seven with molecular relapse/progression. All patients with molecular persistence achieved durable molecular complete remission (CRMRD- ) without transplantation. Six of seven patients with molecular relapse/progression achieved CRMRD- after 1-2 cycles of venetoclax. This paper highlights the promising efficacy of venetoclax-based therapy to reduce the relapse risk in patients with persistent or rising NPM1mut MRD. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الإتاحة: | Open access content. Open access content CC BY-NC https://creativecommons.org/licenses/by-nc/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/274114 Tiong, I. S., Dillon, R., Ivey, A., Teh, T. -C., Nguyen, P., Cummings, N., Taussig, D. C., Latif, A. -L., Potter, N. E., Runglall, M., Russell, N. H., Raj, K., Schwarer, A. P., Fong, C. Y., Grigg, A. P. & Wei, A. H. (2020). Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low-intensity chemotherapy in acute myeloid leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 192 (6), pp.1026-1030. https://doi.org/10.1111/bjh.16722. 10.1111/bjh.16722 1365-2141 0007-1048 1315707960 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315707960 |
| قاعدة البيانات: | OAIster |
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