مورد إلكتروني
Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies
| العنوان: | Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies |
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| المؤلفون: | Tantalo, DGM, Oliver, AJ, von Scheidt, B, Harrison, AJ, Mueller, SN, Kershaw, MH, Slaney, CY |
| بيانات النشر: | BMJ PUBLISHING GROUP 2021-05-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Rapid advances in immunotherapy have identified adoptive cell transfer as one of the most promising approaches for the treatment of cancers. Large numbers of cancer reactive T lymphocytes can be generated ex vivo from patient blood by genetic modification to express chimeric antigen receptors (CAR) specific for tumor-associated antigens. CAR T cells can respond strongly against cancer cells, and adoptive transferred CAR T cells can induce dramatic responses against certain types of cancers. The ability of T cells to respond against disease depends on their ability to localize to sites, persist and exert functions, often in an immunosuppressive microenvironment, and these abilities are reflected in their phenotypes. There is currently intense interest in generating CAR T cells possessing the ideal phenotypes to confer optimal antitumor activity. In this article, we review T cell phenotypes for trafficking, persistence and function, and discuss how culture conditions and genetic makeups can be manipulated to achieve the ideal phenotypes for antitumor activities. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الإتاحة: | Open access content. Open access content CC BY-NC https://creativecommons.org/licenses/by-nc/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/278368 Tantalo, D. G. M., Oliver, A. J., von Scheidt, B., Harrison, A. J., Mueller, S. N., Kershaw, M. H. & Slaney, C. Y. (2021). Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9 (5), https://doi.org/10.1136/jitc-2021-002555. 10.1136/jitc-2021-002555 2051-1426 2051-1426 1315717491 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315717491 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |