مورد إلكتروني
Towards a pragmatic human migraine model for drug testing:2. Isosorbide-5-mononitrate in healthy individuals
| العنوان: | Towards a pragmatic human migraine model for drug testing:2. Isosorbide-5-mononitrate in healthy individuals |
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| المصدر: | Hansen , E K & Olesen , J 2017 , ' Towards a pragmatic human migraine model for drug testing : 2. Isosorbide-5-mononitrate in healthy individuals ' , Cephalalgia : an international journal of headache , vol. 37 , no. 1 , pp. 11-19 . |
| بيانات النشر: | 2017 |
| تفاصيل مُضافة: | Hansen, Emma Katrine Olesen, Jes |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background A model for the testing of novel anti-migraine drugs should preferably use healthy volunteers for ease of recruiting. Isosorbide-5-mononitrate (5-ISMN) provokes headache in healthy volunteers with some migraine features such as pulsating pain quality and aggravation by physical activity. Therefore, this headache might respond to sumatriptan, a requirement for validation of any model. The hypothesis of the present study was that sumatriptan is effective in 5-ISMN-induced headache in healthy individuals. Methods In a double-blind, randomised, crossover design, 30 healthy volunteers of both sexes received 5-ISMN 60 mg on two separate days, each day followed by oral self-administered placebo or sumatriptan 50 mg. Headache response and accompanying symptoms were registered in a questionnaire by the participants themselves. Results 5-ISMN induced a reproducible headache in all 30 participants. The headache had several migraine-like features in all participants and 20 individuals developed a migraine-like attack. Median peak headache score was 5 on both experimental days ( p = 1.00). There was no reduction, but instead an increase in headache intensity 2 hours after sumatriptan ( p = 0.003). Difference in area under the headache score curve (AUC) 0-4 hours between sumatriptan and placebo was not significant ( p = 0.30). Conclusion 5-ISMN is a very powerful inducer of migraine-like headache in healthy individuals but the headache does not respond to sumatriptan. The model is not useful for future drug testing. |
| مصطلحات الفهرس: | Adult, Cross-Over Studies, Double-Blind Method, Female, Healthy Volunteers, Humans, Isosorbide Dinitrate/analogs & derivatives, Male, Middle Aged, Migraine Disorders/chemically induced, Models, Biological, Serotonin 5-HT1 Receptor Agonists/therapeutic use, Sumatriptan/therapeutic use, Vasodilator Agents/toxicity, article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/closedAccess |
| ملاحظة: | English |
| أرقام أخرى: | DAV oai:pure.atira.dk:publications/1670aa9c-4413-43f6-baf8-9f31abf2a9bb 1322708957 |
| المصدر المساهم: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1322708957 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |