مورد إلكتروني
Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation
| العنوان: | Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation |
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| بيانات النشر: | 2007 |
| تفاصيل مُضافة: | Li, John Zhong Ye, Jing Xue, Bofu Qi, Jingzhong Zhang, Jing Zhou, Zhihong Li, Qing Wen, Zilong Li, Peng |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | OBJECTIVE-Our previous study suggests that Cidea, a member of Cide family proteins that share sequence homology with the DNA fragmentation factor and are expressed at high levels in brown adipose tissue, plays an important role in the development of obesity. Cideb, another member of Cide family protein, is highly expressed in the liver. We would like to understand the physiological role of Cideb in the regulation of energy expenditure and lipid metabolism. RESEARCH DESIGN AND METHODS-We generated Cideb-null mice by homolog recombination and then fed both wild-type and Cideb-null mice with high-fat diet (58\% fat). We then characterized the animals' adiposity index, food intake, whole-body metabolic rate, liver morphology, rate of fatty acid synthesis and oxidation, insulin sensitivity, and gene expression profile. RESULTS-Cideb-null mice had lower levels of plasma triglycerides and free fatty acids and were resistant to high-fat diet-induced obesity and live steatosis. In addition, Cideb mutant mice displayed significantly increased insulin sensitivity and enhanced rate of whole-body metabolism and hepatic fatty acid oxidation. More importantly, Cideb-null mice showed decreased lipogenesis and reduced expression levels of acetyl-CoA carboxylase, fatty acid synthase, and stearol-CoA desaturase. We further demonstrated that expression levels of sterol response element binding protein 1c was significantly decreased in Cideb-deficient mice. CONCLUSIONS-Our data demonstrate that Cideb is a novel important regulator in lipid metabolism in the liver. Cideb may represent a new therapeutic target for the treatment of obesity, diabetes, and liver steatosis. |
| مصطلحات الفهرس: | Animals, Apoptosis Regulatory Proteins: deficiency, Apoptosis Regulatory Proteins: genetics, Apoptosis Regulatory Proteins: physiology, Diet, Fatty Acids: metabolism, Fatty Liver: genetics, Insulin: pharmacology, Insulin: physiology, Lipids: biosynthesis, Liver: metabolism, Mice, Mice, Knockout, Mutation, Obesity: genetics, Stearoyl-CoA Desaturase: deficiency, Stearoyl-CoA Desaturase: genetics, Article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | HNK oai:repository.hkust.edu.hk:1783.1-30056 Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532 0012-1797 https://doi.org/10.2337/db07-0040 1331218974 |
| المصدر المساهم: | HONG KONG UNIV OF SCI & TECH, THE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1331218974 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |