مورد إلكتروني
Sarcoma classification by DNA methylation profiling
| العنوان: | Sarcoma classification by DNA methylation profiling |
|---|---|
| المؤلفون: | Koelsche, C, Schrimpf, D, Stichel, D, Sill, M, Sahm, F, Reuss, DE, Blattner, M, Worst, B, Heilig, CE, Beck, K, Horak, P, Kreutzfeldt, S, Paff, E, Stark, S, Johann, P, Selt, F, Ecker, J, Sturm, D, Pajtler, K W, Reinhardt, A, Wefers, AK, Sievers, P, Ebrahimi, A, Suwala, A, Fernandez-Klett, F, Casalini, B, Korshunov, A, Hovestadt, V, Kommoss, FKF, Kriegsmann, M, Schick, M, Bewerunge-Hudler, M, Milde, T, Witt, O, Kulozik, AE, Kool, M, Romero-Perez, L, Grunewald, TGP, Kirchner, T, Wick, W, Platten, M, Unterberg, A, Uhl, M, Abdollahi, A, Debus, J, Lehner, B, Thomas, C, Hasselblatt, M, Paulus, W, Hartmann, C, Staszewski, O, Prinz, M, Hench, J, Frank, S, Versleijen-Jonkers, YMH, Weidema, ME, Mentzel, T, Griewank, K, Alava, E, Martin, JD, Gastearena, MAI, Chang, KTE, Low, SYY, Cuevas-Bourdier, A, Mittelbronn, M, Mynarek, M, Rutkowski, S, Schuller, U, Mautner, VF, Schittenhelm, J, Serrano, J, Snuderl, M, Buttner, R, Klingebiel, T, Buslei, R, Gessler, M, Wesseling, P, Dinjens, Winand, Brandner, S, Jaunmuktane, Z, Lyskjaer, I, Schirmacher, P, Stenzinger, A, Brors, B, Glimm, H, Heining, C, Tirado, OM, Sainz-Jaspeado, M, Mora, J, Alonso, J, del Muro, XG, Moran, S, Esteller, M, Benhamida, JK, Ladanyi, M, Wardelmann, E, Antonescu, C, Flanagan, A, Dirksen, U, Hohenberger, P, Baumhoer, D, Hartmann, W, Vokuhl, C, Flucke, U, Petersen, I, Mechtersheimer, G, Capper, D, Jones, DT, Frohling, S, Pfister, SM, von Deimling, A |
| المصدر: | Koelsche , C , Schrimpf , D , Stichel , D , Sill , M , Sahm , F , Reuss , DE , Blattner , M , Worst , B , Heilig , CE , Beck , K , Horak , P , Kreutzfeldt , S , Paff , E , Stark , S , Johann , P , Selt , F , Ecker , J , Sturm , D , Pajtler , K W , Reinhardt , A , Wefers , AK , Sievers , P , Ebrahimi , A , Suwala , A , Fernandez-Klett , F , Casalini , B , Korshunov , A , Hovestadt , V , Kommoss , FKF , Kriegsmann , M , Schick , M , Bewerunge-Hudler , M , Milde , T , Witt , O , Kulozik , AE , Kool , M , Romero-Perez , L , Grunewald , TGP , Kirchner , T , Wick , W , Platten , M , Unterberg , A , Uhl , M , Abdollahi , A , Debus , J , Lehner , B , Thomas , C , Hasselblatt , M , Paulus , W , Hartmann , C , Staszewski , O , Prinz , M , Hench , J , Frank , S , Versleijen-Jonkers , YMH , Weidema , ME , Mentzel , T , Griewank , K , Alava , E , Martin , JD , Gastearena , MAI , Chang , KTE , Low , SYY , Cuevas-Bourdier , A , Mittelbronn , M , Mynarek , M , Rutkowski , S , Schuller , U , Mautner , VF , Schittenhelm , J , Serrano , J , Snuderl , M , Buttner , R , Klingebiel , T , Buslei , R , Gessler , M , Wesseling , P , Dinjens , W , Brandner , S , Jaunmuktane , Z , Lyskjaer , I , Schirmacher , P , Stenzinger , A , Brors , B , Glimm , H , Heining , C , Tirado , OM , Sainz-Jaspeado , M , Mora , J , Alonso , J , del Muro , XG , Moran , S , Esteller , M , Benhamida , JK , Ladanyi , M , Wardelmann , E , Antonescu , C , Flanagan , A , Dirksen , U , Hohenberger , P , Baumhoer , D , Hartmann , W , Vokuhl , C , Flucke , U , Petersen , I , Mechtersheimer , G , Capper , D , Jones , DT , Frohling , S , Pfister , SM & von Deimling , A 2021 , ' Sarcoma classification by DNA methylation profiling ' , Nature Communications , vol. 12 , no. 1 , 498 . |
| بيانات النشر: | 2021-01-21 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications. |
| مصطلحات الفهرس: | dk/atira/pure/keywords/researchprograms/AFL001000/EMCOR01; name=EMC OR-01, article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | QGQ oai:pure.eur.nl:publications/787dc0a1-033f-4245-ae1c-718e4756fb8c https://pure.eur.nl/en/publications/787dc0a1-033f-4245-ae1c-718e4756fb8c https://doi.org/10.1038/s41467-020-20603-4 https://pure.eur.nl/ws/files/58916468/s41467_020_20603_4.pdf https://www.nature.com/articles/s41467-020-20603-4.pdf 1338020223 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1338020223 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |