مورد إلكتروني
In Vivo Confocal Microscopy of the Corneal-Conjunctival Transition in the Evaluation of Epithelial Renewal after SLET
| العنوان: | In Vivo Confocal Microscopy of the Corneal-Conjunctival Transition in the Evaluation of Epithelial Renewal after SLET |
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| بيانات النشر: | Linköpings universitet, Avdelningen för sinnesorgan och kommunikation Linköpings universitet, Medicinska fakulteten Region Östergötland, Ögonkliniken US Univ Verona, Italy Univ Verona, Italy Univ Verona, Italy Univ Verona, Italy San Bassiano Hosp, Italy Univ Verona, Italy; Veneto Eye Bank Fdn, Italy Univ Verona, Italy Univ Verona, Italy Univ Verona, Italy MDPI 2020 |
| تفاصيل مُضافة: | Pedrotti, Emilio Chierego, Chiara Cozzini, Tiziano Merz, Tommaso Lagali, Neil De Gregorio, Alessandra Fasolo, Adriano Bonacci, Erika Bonetto, Jacopo Marchini, Giorgio |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Examination of the corneal surface by in vivo confocal microscopy (IVCM) allows for objective identification of corneal and conjunctival cell phenotypes to evaluate different epithelialization patterns. Detection of a corneal-conjunctival epithelial transition could be considered as a sign of restored epithelial function following simple limbal epithelial transplantation (SLET). This is a prospective, interventional case series. We assessed patients with limbal stem cell deficiency (LSCD) by IVCM, preoperatively and at monthly intervals following SLET. Sectors in the central and peripheral cornea were scanned. Immediately upon detection of multi-layered cells with the epithelial phenotype in the central cornea and confirmation of epithelial transition in all corneal sectors, the decision for keratoplasty was taken. Ten patients were enrolled. After SLET, epithelial phenotype in the central cornea and an epithelial transition were identified within six and nine months in seven and one patients, respectively. One patient was a partial success and one failed. Five patients underwent keratoplasty, with stable results up to 12 months. Identification of the epithelial transition zone by IVCM permits assessment of the efficacy of SLET, enabling subsequent planning of keratoplasty for visual rehabilitation. The stability of the corneal surface following keratoplasty confirms that the renewal of the corneal epithelium was effectively retained. |
| مصطلحات الفهرس: | in vivo confocal microscopy; simple limbal epithelial transplantation; corneal-conjunctival epithelial transition; keratoplasty; limbal stem cell deficiency, Ophthalmology, Oftalmologi, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.3390.jcm9113574 |
| URL: | Journal of Clinical Medicine, 2020, 9:11 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | UPE oai:DiVA.org:liu-171969 0000-0003-1079-4361 doi:10.3390/jcm9113574 PMID 33171960 ISI:000593372100001 1349014631 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1349014631 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.3390.jcm9113574 |
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