مورد إلكتروني
Pentraxin 3 Levels Correlate well with Disease Severity at Admission in COVID-19 Patients
| العنوان: | Pentraxin 3 Levels Correlate well with Disease Severity at Admission in COVID-19 Patients |
|---|---|
| عناروين إضافية: | Razine pentraksina 3 dobro su povezane s težinom bolesti kod prijma u bolesnika s COVID-19 |
| المصدر: | Acta clinica Croatica; ISSN 0353-9466 (Print); ISSN 1333-9451 (Online); Volume 61.; Issue 2 |
| بيانات النشر: | Sestre Milosrdnice University hospital and Institute of Clinical Medical Research 2022 |
| تفاصيل مُضافة: | Işık, Mehmet Emirhan Korkusuz, Ramazan Erdal Şahingöz, Gülçin Işık, Arzu Cennet Karagöz, Ali Işıksaçan, Nilgün Kalkanlı Taş, Sevgi Kart Yaşar, Kadriye |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections. In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found to be significantly increased at admission and showed significant association with the disease severity. Pentraksin 3 (PTX3), dugi pentraksin, ne oslobađa se samo iz dendritičnih stanica i neutrofila, nego i iz epitelnih i endotelnih stanica poput alveolarnog epitela. Teški akutni respiracijski sindrom koronavirus-2 (SARS-CoV-2) u početku aktivira urođeni imuni sustav uzrokujući složen imuni odgovor. Klinička i eksperimentalna istraživanja ukazuju na to da se PTX3, lokalno i sistemski izlučeni biljeg, može koristiti kao prediktor težine i smrtnosti kod respiracijskih infekcija. U ovom istraživanju utvrđeno je da su razine PTX3 u serumu bolesnika hospitaliziranih s COVID-19 bile značajno povišene kod prijma i značajno povezane s težinom bolesti. |
| مصطلحات الفهرس: | COVID-19; Pentraxin 3; Innate immunity; C-reactive protein; SARS-CoV-2, COVID-19; Pentraksin 3; Urođeni imunitet; C-reaktivni protein; SARS-CoV-2, text, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | info:eu-repo/semantics/altIdentifier/doi/10.20471/acc.2022.61.02.17 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0 |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | HRCAK oai:hrcak.srce.hr:284793 1350161632 |
| المصدر المساهم: | HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1350161632 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |