مورد إلكتروني
Maternal-derived antibodies hinder the antibody response to H9N2 AIV inactivated vaccine in the field
| العنوان: | Maternal-derived antibodies hinder the antibody response to H9N2 AIV inactivated vaccine in the field |
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| المصدر: | ISSN: 2731-0442 |
| بيانات النشر: | 2022 |
| تفاصيل مُضافة: | Pan, Xue Su, Xin Ding, Pingyun Zhao, Jinhua Cui, Hongrui Yan, Dawei Teng, Qiaoyang Li, Xuesong Beerens, Nancy Zhang, Haitao Liu, Qinfang de Jong, Mart C.M. Li, Zejun |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The H9N2 subtype avian influenza virus (AIV) inactivated vaccine has been used extensively in poultry farms, but it often fails to stimulate a sufficiently high immune response in poultry in the field, although it works well in laboratory experiments; hence, the virus still causes economic damage every year and poses a potential threat to public health. Based on surveillance data collected in the field, we found that broilers with high levels of maternal-derived antibodies (MDAs) against H9N2 virus did not produce high levels of antibodies after vaccination with a commercial H9N2 inactivated vaccine. In contrast, specific pathogen-free (SPF) chickens without MDAs responded efficiently to that vaccination. When MDAs were mimicked by administering passively transferred antibodies (PTAs) into SPF chickens in the laboratory, similar results were observed: H9N2-specific PTAs inhibited humoral immunity against the H9N2 inactivated vaccine, suggesting that H9N2-specific MDAs might hinder the generation of antibodies when H9N2 inactivated vaccine was used. After challenge with homologous H9N2 virus, the virus was detected in oropharyngeal swabs of the vaccinated and unvaccinated chickens with PTAs but not in the vaccinated chickens without PTAs, indicating that H9N2-specific MDAs were indeed one of the reasons for H9N2 inactivated vaccine failure in the field. When different titers of PTAs were used to mimic MDAs in SPF chickens, high (HI = 12 log2) and medium (HI = log 9 log2) titers of PTAs reduced the generation of H9N2-specific antibodies after the first vaccination, but a booster dose would induce a high and faster humoral immune response even of PTA interference. This study strongly suggested that high or medium titers of MDAs might explain H9N2 inactivated vaccine failure in the field. |
| مصطلحات الفهرس: | H9N2 avian influenza virus (AIV), Humoral immune response, Maternal-derived antibodies (MDAs), Passively transferred antibodies (PTAs), Vaccination failure, info:eu-repo/semantics/article, Article/Letter to editor, info:eu-repo/semantics/publishedVersion |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0 Wageningen University & Research |
| ملاحظة: | application/pdf Animal Diseases 2 (2022) 1 ISSN: 2731-0442 ISSN: 2731-0442 English |
| أرقام أخرى: | NLWUP oai:library.wur.nl:wurpubs/603362 https://research.wur.nl/en/publications/maternal-derived-antibodies-hinder-the-antibody-response-to-h9n2- 10.1186/s44149-022-00040-0 1350175843 |
| المصدر المساهم: | WUR STAFF PUBNS From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1350175843 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |