مورد إلكتروني
Ecophysiology of novel intestinal butyrate-producing bacteria
| العنوان: | Ecophysiology of novel intestinal butyrate-producing bacteria |
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| بيانات النشر: | Wageningen University 2016 |
| تفاصيل مُضافة: | Bui, Thi Phuong Nam |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The human intestinal tract harbours a trillion on microbial cells, predominantly anaerobes. The activity and physiology of these anaerobes is strongly associated with health and disease. This association has been investigated for a long time.However, this has not been fully understood. One of the reasons is the limited availability of cultured representatives. It is estimated that there may be more than 3000 species colonised in the gut of healthy individuals, however, only a bit over 1000 species have been isolated and characterised. Among the intestinal microbes, butyrate-producing bacteria are of special interest as the butyrate produced, is crucial to maintain a healthy gut. In addition, butyrate-producing bacteria have shown a reverse correlation with several intestinal diseases. In Chapter 2 we described a novel species Anaerostipes rhamnosivorans 1y2T isolated from an infant stool. This strain belonged to genus Anaerostipes within Clostridium cluster XIVa. A. rhamnosivorans had a capability of converting rhamnose into butyrate that is unique within intestinal butyrate-producing bacteria. The genomic analysis also revealed the entire rhamnose fermentation pathway as well as the acetyl-CoA pathway for butyrate production. This bacterium is able to produce butyrate from a wide range of sugars as well as lactate plus acetate. In Chapter 3, we described the microbial interactions between A. rhamnosivorans and Bacteriodes thetaiotaomicron in dietary pectins; Blautia hydrogenotrophica in lactate and small amount of acetate; Methanobrevibacter smithii in glucose. We observed that A. rhamnosivorans was able to benefit from its partners in all cocultures for butyrate production. This is likely due to its high metabolic flexibility. While the interaction between A. rhamnosivorans and B. thetaiotaomicron appeared as syntrophy, the interaction between A. rhamnosivorans and hydrogenotrohic microbes were cross-feeding type where hydrogen was transferred between two species. |
| مصطلحات الفهرس: | biochemical pathways, butyrates, butyric acid bacteria, faecal examination, genomics, infants, intestinal physiology, intestines, lysine, man, mice, microbial interactions, microbial physiology, sugar, biochemische omzettingen, boterzuurbacteriën, butyraten, darmen, darmfysiologie, fecesonderzoek, genomica, mens, microbiële fysiologie, microbiële interacties, muizen, suiker, zuigelingen, info:eu-repo/semantics/doctoralThesis, Doctoral thesis, info:eu-repo/semantics/publishedVersion |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Wageningen University & Research |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | NLWUP oai:library.wur.nl:wurpubs/499535 https://research.wur.nl/en/publications/ecophysiology-of-novel-intestinal-butyrate-producing-bacteria 1350183699 |
| المصدر المساهم: | WUR STAFF PUBNS From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1350183699 |
| قاعدة البيانات: | OAIster |
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