مورد إلكتروني
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis
| العنوان: | Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis |
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| بيانات النشر: | 2021 |
| تفاصيل مُضافة: | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Física Aplicada III Selvaraj, Emmanuel Anandraj Mozes, Ferenc Emil Ajmer Jayaswal, Arjun Narayan Zafarmand, Mohammad Hadi Vali, Yasaman Lee, Jenny A. Romero Gómez, Manuel Ampuero Herrojo, Javier Gómez-González, Emilio |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2- dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) have been proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH). Methods: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests, against histology as the reference standard, in adult patients with NAFLD. Two authors independently screened and assessed methodological quality of studies and extracted data. Summary estimates of sensitivity, specificity and area under the curve (sAUC) were calculated for fibrosis stages and NASH, using a random effects bivariate logit-normal model. Results: We included 82 studies (14,609 patients). Meta-analysis for diagnosing fibrosis stages was possible in 53 VCTE, 11 MRE, 12 pSWE and 4 2DSWE studies, and for diagnosing NASH in 4 MRE studies. sAUC for diagnosis of significant fibrosis were: 0.83 for VCTE, 0.91 for MRE, 0.86 for pSWE and 0.75 for 2DSWE. sAUC for diagnosis of advanced fibrosis were: 0.85 for VCTE, 0.92 for MRE, 0.89 for pSWE and 0.72 for 2DSWE. sAUC for diagnosis of cirrhosis were: 0.89 for VCTE, 0.90 for MRE, 0.90 for pSWE and 0.88 for 2DSWE. MRE had sAUC of 0.83 for diagnosis of NASH. Three (4%) studies reported intention-to-diagnose analyses and 15 (18%) studies reported diagnostic accuracy against prespecified cut-offs. Conclusions: When elastography index tests are acquired successfully, they have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these index tests cannot be assessed fully as intention-to-diagnose analyses and validation of pre-specified thresholds are lacking. Lay summary: Non-invasive tests that measu |
| مصطلحات الفهرس: | Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Biomarkers, Liver fibrosis, Transient elastography, Shear wave elastography, Magnetic resonance elastography, Iron-corrected T1, Diffusion-weighted imaging, deMILI, fibro-MR, NASH-MRI, info:eu-repo/semantics/article |
| URL: | |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| ملاحظة: | English |
| أرقام أخرى: | SUE oai:idus.us.es:11441/139090 0168-8278 1600-0641 (electrónico) 10.1016/j.jhep.2021.04.044 1356791415 |
| المصدر المساهم: | UNIV DE SEVILLA From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1356791415 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |