مورد إلكتروني
Systematic mutational analysis of the intracellular regions of yeast Gap1 permease.
| العنوان: | Systematic mutational analysis of the intracellular regions of yeast Gap1 permease. |
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| المصدر: | PloS one, 6 (4 |
| بيانات النشر: | 2011 |
| تفاصيل مُضافة: | Merhi, Ahmad Gerard, Nicolas Lauwers, Elsa Prévost, Martine André, Bruno |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The yeast general amino acid permease Gap1 is a convenient model for studying the intracellular trafficking of membrane proteins. Present at the plasma membrane when the nitrogen source is poor, it undergoes ubiquitin-dependent endocytosis and degradation upon addition of a good nitrogen source, e.g. ammonium. It comprises 12 transmembrane domains (TM) flanked by cytosol-facing N- and C-terminal tails (NT, CT). The NT of Gap1 contains the acceptor lysines for ubiquitylation and its CT includes a sequence essential to exit from the endoplasmic reticulum (ER). Journal Article Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Biologie moléculaire, Alleles, Amino Acid Sequence, Amino Acid Transport Systems -- chemistry -- genetics, DNA Mutational Analysis, Down-Regulation -- drug effects, Genes, Fungal -- genetics, Lysine -- metabolism, Membrane Transport Proteins -- chemistry -- genetics, Models, Molecular, Molecular Sequence Data, Mutant Proteins -- chemistry -- genetics, Phenotype, Protein Structure, Tertiary, Quaternary Ammonium Compounds -- pharmacology, Saccharomyces cerevisiae -- drug effects -- enzymology -- genetics -- growth & development, Saccharomyces cerevisiae Proteins -- chemistry -- genetics, Subcellular Fractions -- drug effects -- metabolism, Ubiquitin -- metabolism, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content 1 full-text file(s): info:eu-repo/semantics/openAccess |
| ملاحظة: | 1 full-text file(s): application/pdf English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/98870 uri/info:doi/10.1371/journal.pone.0018457 uri/info:pmid/21526172 uri/info:scp/79955454220 uri/info:pmcid/PMC3079708 1363669000 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363669000 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |