مورد إلكتروني
Effects of vasodilators on gas exchange in acute canine embolic pulmonary hypertension.
| العنوان: | Effects of vasodilators on gas exchange in acute canine embolic pulmonary hypertension. |
|---|---|
| المصدر: | Anesthesiology, 72 (1 |
| بيانات النشر: | 1990-01 |
| تفاصيل مُضافة: | Delcroix, Marion Melot, Christian Lejeune, Philippe Leeman, Marc Naeije, Robert |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Pulmonary vascular tone was investigated by the construction of pulmonary arterial pressure (PAP)/cardiac output (Q) plots, and gas exchange, by the multiple inert gas elimination technique, in 24 anesthetized dogs before and after pulmonary embolization of autologous clots. Three PAP/Q plots were obtained by a manipulation of venous return at baseline and 60 min and 110 min after embolization. Before the third PAP/Q plot, the dogs were randomly allocated to one of the following iv treatments: 1) placebo (n = 6); 2) prostaglandin E1 (PGE1) 0.4 microgram.kg-1.min-1 (n = 6); 3) hydralazine 2 mg/kg (n = 6); and 4) nitroprusside 10 microgram.kg-1.min-1 (n = 6). These vasodilators decreased systemic arterial pressure by a mean of 44%. Ventilation-perfusion (VA/Q) distributions were determined at the same Q (2.4 +/- 0.1 l.min-1.m-2, mean +/- SE) of each PAP/Q plot. Embolization increased the intercept and the slope of the PAP/Q plots (P less than 0.001). Distributions of VA/Q were only moderately impaired, with an increased dispersion of both VA and Q and a shift of VA distributions to higher VA/Q. PaO2 changed from 208 +/- 5 to 172 +/- 8 mmHg (P less than 0.01) (fraction of inspired O2 was 0.4). None of the treatments had any effect on VA/Q distributions. Placebo and PGE1 had no effect on PAP/Q plots. Hydralazine and nitroprusside reduced the slope of the PAP/Q plots. Thus, in this canine model of acute pulmonary embolism: 1) VA/Q distributions were moderately impaired accounting for only slight hypoxemia, and 2) pulmonary hypertension was partially reversible by hydralazine and by nitroprusside without associated non-flow-dependent change in VA/Q distributions and arterial oxygenation. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Physiologie générale, Acute Disease, Alprostadil -- therapeutic use, Animals, Dogs, Hydralazine -- therapeutic use, Hypertension, Pulmonary -- drug therapy -- physiopathology, Nitroprusside -- therapeutic use, Pulmonary Embolism -- drug therapy -- physiopathology, Pulmonary Gas Exchange -- drug effects, Vasodilator Agents -- therapeutic use, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | No full-text files English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/97019 uri/info:pmid/2297136 1363685738 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363685738 |
| قاعدة البيانات: | OAIster |
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