مورد إلكتروني
New esters of succinic acid and mixed molecules formed by such esters and a meglitinide analog: study of their insulinotropic potential.
| العنوان: | New esters of succinic acid and mixed molecules formed by such esters and a meglitinide analog: study of their insulinotropic potential. |
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| المصدر: | Pharmacological research, 41 (5 |
| بيانات النشر: | 2000-05 |
| تفاصيل مُضافة: | Laghmich, Aouatif Dannacher, H Björkling, Fredrik Malaisse, Willy Ladrière, Laurence |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Eighteen novel esters of succinic acid, including three mixed molecules formed of both succinic acid and nateglinide, were examined for their insulinotropic efficiency in isolated rat pancreatic islets. The secretory response to these esters at increasing concentrations of both d -glucose and the ester itself allowed to identify five esters judged of potential interest for further investigations. They include three molecules with CH(3)-O-CO-CH(2)-CH(2)-CO-NH-CH(R)-CO-O- sequence and two mixed molecules with a nateglinide moiety. The effects of the most potent molecule in the first group and that of two of the esters with a nateglinide moiety upon islet biosynthetic activity in vitro and insulin release in vivo, after either oral or intravenous administration were also investigated. The results suggested that mixed molecules formed of both a succinic acid ester and a meglitinide analog may efficiently stimulate proinsulin biosynthesis and/or insulin release. Further work is required, however, to improve their modality of in vivo administration. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Benzamides -- pharmacology, Female, Hypoglycemic Agents -- pharmacology, Islets of Langerhans -- drug effects, Islets of Langerhans -- metabolism, Proinsulin -- biosynthesis, Rats, Rats, Wistar, Succinates -- pharmacology, Nateglinide, Rat pancreatic islet biosynthetic and secretory activity, Succinic acid esters, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | No full-text files English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/50590 uri/info:doi/10.1006/phrs.1999.0626 uri/info:pii/S1043-6618(99)90626-6 uri/info:pmid/10753554 uri/info:scp/0033848090 1363712229 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363712229 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |